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Foxj3 forkhead box J3 [ Mus musculus (house mouse) ]

Gene ID: 230700, updated on 18-Apr-2024

Summary

Official Symbol
Foxj3provided by MGI
Official Full Name
forkhead box J3provided by MGI
Primary source
MGI:MGI:2443432
See related
Ensembl:ENSMUSG00000032998 AllianceGenome:MGI:2443432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhd6; C330039G02Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male meiosis I and spermatogenesis. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human FOXJ3 (forkhead box J3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.4), whole brain E14.5 (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D2.1; 4 55.43 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119396858..119486316)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119539661..119629119)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene U6 small nuclear RNA, pseudogene 2 Neighboring gene FSHD region gene 2 family member 1 Neighboring gene STARR-seq mESC enhancer starr_11236 Neighboring gene STARR-seq mESC enhancer starr_11239 Neighboring gene guanylate cyclase activator 2a (guanylin) Neighboring gene guanylate cyclase activator 2b (retina)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 
  • Gene trapped (1) 

General gene information

Markers

Clone Names

  • KIAA1041, DKFZp761E2211

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
forkhead box protein J3
Names
forkhead domain gene 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290696.1NP_001277625.1  forkhead box protein J3 isoform 2

    See identical proteins and their annotated locations for NP_001277625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK077346, AK082840, BP763140, CB245622, CJ048244
    Consensus CDS
    CCDS71462.1
    UniProtKB/Swiss-Prot
    Q8BUR3
    Related
    ENSMUSP00000101917.3, ENSMUST00000106310.9
    Conserved Domains (2) summary
    pfam15258
    Location:332404
    FAM222A; Protein family of FAM222A
    cd20024
    Location:78154
    FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins
  2. NM_001357177.1NP_001344106.1  forkhead box protein J3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK077346, AK082840, AK139508, AL645563, BP763140
    Consensus CDS
    CCDS18585.1
    UniProtKB/Swiss-Prot
    A2AA37, A2AA38, Q3UTD8, Q8BUR3
    Conserved Domains (3) summary
    COG5025
    Location:54347
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam00250
    Location:78155
    Forkhead; Forkhead domain
    pfam09770
    Location:311434
    PAT1; Topoisomerase II-associated protein PAT1
  3. NM_172699.3NP_766287.1  forkhead box protein J3 isoform 1

    See identical proteins and their annotated locations for NP_766287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK077346, AK082840, AK139508, BP763140
    Consensus CDS
    CCDS18585.1
    UniProtKB/Swiss-Prot
    A2AA37, A2AA38, Q3UTD8, Q8BUR3
    Related
    ENSMUSP00000035746.9, ENSMUST00000044564.15
    Conserved Domains (3) summary
    COG5025
    Location:54347
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam00250
    Location:78155
    Forkhead; Forkhead domain
    pfam09770
    Location:311434
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119396858..119486316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503017.5XP_006503080.1  forkhead box protein J3 isoform X1

    See identical proteins and their annotated locations for XP_006503080.1

    UniProtKB/Swiss-Prot
    A2AA37, A2AA38, Q3UTD8, Q8BUR3
    Conserved Domains (3) summary
    COG5025
    Location:54347
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam00250
    Location:78155
    Forkhead; Forkhead domain
    pfam09770
    Location:311434
    PAT1; Topoisomerase II-associated protein PAT1
  2. XM_036164038.1XP_036019931.1  forkhead box protein J3 isoform X2

    Conserved Domains (2) summary
    pfam15258
    Location:332404
    FAM222A; Protein family of FAM222A
    cd20024
    Location:78154
    FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins
  3. XM_036164039.1XP_036019932.1  forkhead box protein J3 isoform X2

    Conserved Domains (2) summary
    pfam15258
    Location:332404
    FAM222A; Protein family of FAM222A
    cd20024
    Location:78154
    FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins