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ENDOD1 endonuclease domain containing 1 [ Homo sapiens (human) ]

Gene ID: 23052, updated on 1-Jun-2020


Official Symbol
ENDOD1provided by HGNC
Official Full Name
endonuclease domain containing 1provided by HGNC
Primary source
See related
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Ubiquitous expression in prostate (RPKM 33.4), brain (RPKM 27.7) and 24 other tissues See more

Genomic context

See ENDOD1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (95089846..95132645)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94822974..94865815)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4D pseudogene Neighboring gene serine and arginine rich splicing factor 8 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4868 Neighboring gene BUD13 homolog pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with endonuclease domain containing 1 (ENDOD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • KIAA0830, MGC88092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
metal ion binding IEA
Inferred from Electronic Annotation
more info
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
platelet degranulation TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
membrane HDA PubMed 

General protein information

Preferred Names
endonuclease domain-containing 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015036.3NP_055851.1  endonuclease domain-containing 1 protein precursor

    See identical proteins and their annotated locations for NP_055851.1

    Status: VALIDATED

    Source sequence(s)
    AP000787, BC071171, DA050413
    Consensus CDS
    ENSP00000278505.4, ENST00000278505.5
    Conserved Domains (1) summary
    NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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