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ALDOC aldolase, fructose-bisphosphate C [ Homo sapiens (human) ]

Gene ID: 230, updated on 3-Dec-2023

Summary

Official Symbol
ALDOCprovided by HGNC
Official Full Name
aldolase, fructose-bisphosphate Cprovided by HGNC
Primary source
HGNC:HGNC:418
See related
Ensembl:ENSG00000109107 MIM:103870; AllianceGenome:HGNC:418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALDC
Summary
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 270.0), fat (RPKM 67.7) and 5 other tissues See more
Orthologs
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Genomic context

See ALDOC in Genome Data Viewer
Location:
17q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28573120..28576895, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29515745..29519520, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26900138..26903913, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26873952-26874789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26874790-26875626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8343 Neighboring gene unc-119 lipid binding chaperone Neighboring gene phosphatidylinositol glycan anchor biosynthesis class S Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26897886-26898082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11933 Neighboring gene sperm associated antigen 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26925705-26926249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11934 Neighboring gene SPAG5 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:26938368-26939567 Neighboring gene ribosomal protein S6 kinase related

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of fructose-bisphosphate aldolase C (ALDOC) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fructose metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoskeleton IC
Inferred by Curator
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fructose-bisphosphate aldolase C
Names
aldolase 3
aldolase C, fructose-bisphosphate
brain-type aldolase
epididymis secretory sperm binding protein
fructoaldolase C
fructose-1,6-biphosphate triosephosphate lyase
NP_005156.1
XP_005258006.1
XP_011522858.1
XP_054171518.1
XP_054171519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005165.3NP_005156.1  fructose-bisphosphate aldolase C

    See identical proteins and their annotated locations for NP_005156.1

    Status: REVIEWED

    Source sequence(s)
    AC005726, AF054987, BF345067
    Consensus CDS
    CCDS11236.1
    UniProtKB/Swiss-Prot
    B2R5R3, P09972, Q3SYL3, Q6FH94, Q6P0L5
    UniProtKB/TrEMBL
    A0A024QZ64, B7Z1Y2
    Related
    ENSP00000226253.4, ENST00000226253.9
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    28573120..28576895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524556.3XP_011522858.1  fructose-bisphosphate aldolase C isoform X1

    See identical proteins and their annotated locations for XP_011522858.1

    UniProtKB/Swiss-Prot
    B2R5R3, P09972, Q3SYL3, Q6FH94, Q6P0L5
    UniProtKB/TrEMBL
    A0A024QZ64, B7Z1Y2
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. XM_005257949.3XP_005258006.1  fructose-bisphosphate aldolase C isoform X1

    See identical proteins and their annotated locations for XP_005258006.1

    UniProtKB/Swiss-Prot
    B2R5R3, P09972, Q3SYL3, Q6FH94, Q6P0L5
    UniProtKB/TrEMBL
    A0A024QZ64, B7Z1Y2
    Related
    ENSP00000378731.2, ENST00000395321.6
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    29515745..29519520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315544.1XP_054171519.1  fructose-bisphosphate aldolase C isoform X1

    UniProtKB/Swiss-Prot
    B2R5R3, P09972, Q3SYL3, Q6FH94, Q6P0L5
    UniProtKB/TrEMBL
    A0A024QZ64, B7Z1Y2
  2. XM_054315543.1XP_054171518.1  fructose-bisphosphate aldolase C isoform X1

    UniProtKB/Swiss-Prot
    B2R5R3, P09972, Q3SYL3, Q6FH94, Q6P0L5
    UniProtKB/TrEMBL
    A0A024QZ64, B7Z1Y2