U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pias3 protein inhibitor of activated STAT 3 [ Mus musculus (house mouse) ]

Gene ID: 229615, updated on 5-Jan-2023

Summary

Official Symbol
Pias3provided by MGI
Official Full Name
protein inhibitor of activated STAT 3provided by MGI
Primary source
MGI:MGI:1913126
See related
Ensembl:ENSMUSG00000028101 AllianceGenome:MGI:1913126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pias3l
Summary
Enables SUMO transferase activity. Acts upstream of or within several processes, including TNFSF11-mediated signaling pathway; negative regulation of macromolecule metabolic process; and negative regulation of osteoclast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and maxillary process. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.6), ovary adult (RPKM 8.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pias3 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96603679..96613386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96696361..96706070)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene ankyrin repeat domain 35 Neighboring gene nudix hydrolase 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene predicted gene, 22581 Neighboring gene ring finger protein 115

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC27936

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within TNFSF11-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS3
Names
E3 SUMO-protein transferase PIAS3
protein inhibitor of activated STAT protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165949.1NP_001159421.1  E3 SUMO-protein ligase PIAS3 isoform 3

    See identical proteins and their annotated locations for NP_001159421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    BB042656, BC051252, BE989927, BY154092
    Consensus CDS
    CCDS51007.1
    UniProtKB/Swiss-Prot
    O54714, Q8R598
    UniProtKB/TrEMBL
    A0A8C6HSA2
    Related
    ENSMUSP00000069259.10, ENSMUST00000064900.16
    Conserved Domains (3) summary
    smart00513
    Location:1136
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:323371
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:126263
    PINIT; PINIT domain
  2. NM_018812.2NP_061282.2  E3 SUMO-protein ligase PIAS3 isoform 2

    See identical proteins and their annotated locations for NP_061282.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BB042656, BC050988, BE989927, BY154092
    Consensus CDS
    CCDS17645.2
    UniProtKB/Swiss-Prot
    O54714
    UniProtKB/TrEMBL
    A0A8C6HTU7
    Related
    ENSMUSP00000102692.4, ENSMUST00000107077.4
    Conserved Domains (3) summary
    smart00513
    Location:1136
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:288336
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:91228
    PINIT; PINIT domain
  3. NM_146135.2NP_666247.1  E3 SUMO-protein ligase PIAS3 isoform 1

    See identical proteins and their annotated locations for NP_666247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK040619, BB042656, BE989927, BY002850
    Consensus CDS
    CCDS38559.1
    UniProtKB/Swiss-Prot
    O54714
    Related
    ENSMUSP00000102691.4, ENSMUST00000107076.10
    Conserved Domains (3) summary
    smart00513
    Location:227
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:315362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119263
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96603679..96613386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252586.2XP_030108446.1  E3 SUMO-protein ligase PIAS3 isoform X2

    Conserved Domains (3) summary
    smart00513
    Location:227
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:280327
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:84228
    PINIT; PINIT domain
  2. XM_006501393.2XP_006501456.1  E3 SUMO-protein ligase PIAS3 isoform X1

    See identical proteins and their annotated locations for XP_006501456.1

    UniProtKB/Swiss-Prot
    O54714
    Conserved Domains (3) summary
    smart00513
    Location:227
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:315362
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:119263
    PINIT; PINIT domain
  3. XM_036163073.1XP_036018966.1  E3 SUMO-protein ligase PIAS3 isoform X3

    Conserved Domains (1) summary
    cd16790
    Location:146
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

RNA

  1. XR_004941309.1 RNA Sequence

  2. XR_004941310.1 RNA Sequence

    Related
    ENSMUST00000162934.8
  3. XR_001783683.3 RNA Sequence

  4. XR_001783684.3 RNA Sequence