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PIAS3 protein inhibitor of activated STAT 3 [ Homo sapiens (human) ]

Gene ID: 10401, updated on 1-Jun-2020

Summary

Official Symbol
PIAS3provided by HGNC
Official Full Name
protein inhibitor of activated STAT 3provided by HGNC
Primary source
HGNC:HGNC:16861
See related
Ensembl:ENSG00000131788 MIM:605987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZMIZ5
Summary
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 17.3), skin (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See PIAS3 in Genome Data Viewer
Location:
1q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145848522..145859081, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145575257..145586546)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD160 molecule Neighboring gene ring finger protein 115 Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene microRNA 6736 Neighboring gene ankyrin repeat domain 35 Neighboring gene uncharacterized LOC107985593

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates PIAS3 expression in primary human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14651

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
TNFSF11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS3
Names
E3 SUMO-protein transferase PIAS3
protein inhibitor of activated STAT protein 3
zinc finger, MIZ-type containing 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006099.3NP_006090.2  E3 SUMO-protein ligase PIAS3

    See identical proteins and their annotated locations for NP_006090.2

    Status: REVIEWED

    Source sequence(s)
    AK027557, AL160282, BE247489
    Consensus CDS
    CCDS72866.1
    UniProtKB/Swiss-Prot
    Q9Y6X2
    UniProtKB/TrEMBL
    B3KNI3
    Related
    ENSP00000376765.2, ENST00000393045.7
    Conserved Domains (3) summary
    smart00513
    Location:1136
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:323371
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:126263
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    145848522..145859081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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