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SCAP SREBF chaperone [ Homo sapiens (human) ]

Gene ID: 22937, updated on 11-Jun-2021

Summary

Official Symbol
SCAPprovided by HGNC
Official Full Name
SREBF chaperoneprovided by HGNC
Primary source
HGNC:HGNC:30634
See related
Ensembl:ENSG00000114650 MIM:601510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in adrenal (RPKM 22.6), testis (RPKM 19.9) and 25 other tissues See more
Orthologs
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Genomic context

See SCAP in Genome Data Viewer
Location:
3p21.31
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47413681..47477126, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47455171..47517431, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 18 Neighboring gene protein tyrosine phosphatase non-receptor type 23 Neighboring gene uncharacterized LOC105377073 Neighboring gene bolA family member 2 pseudogene 2 Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene uncharacterized LOC105377074

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in SREBP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
 
involved_in positive regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus NAS
Non-traceable Author Statement
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sterol regulatory element-binding protein cleavage-activating protein
Names
SREBP cleavage-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320044.2NP_001306973.1  sterol regulatory element-binding protein cleavage-activating protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC099778, AK300311, BG179218, CN313163
    UniProtKB/TrEMBL
    B7Z6H0
    Conserved Domains (4) summary
    COG2319
    Location:683979
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:53202
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:703749
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:822979
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_012235.4NP_036367.2  sterol regulatory element-binding protein cleavage-activating protein isoform 1

    See identical proteins and their annotated locations for NP_036367.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC099778, BG179218, D83782
    Consensus CDS
    CCDS2755.2
    UniProtKB/Swiss-Prot
    Q12770
    Related
    ENSP00000265565.5, ENST00000265565.10
    Conserved Domains (4) summary
    COG2319
    Location:9391235
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:308457
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:9591005
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10781235
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    47413681..47477126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533501.1XP_011531803.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    See identical proteins and their annotated locations for XP_011531803.1

    UniProtKB/Swiss-Prot
    Q12770
    Conserved Domains (4) summary
    COG2319
    Location:9391235
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:308457
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:9591005
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10781235
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_005264968.1XP_005265025.1  sterol regulatory element-binding protein cleavage-activating protein isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:684980
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:53202
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:704750
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:823980
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017005921.1XP_016861410.1  sterol regulatory element-binding protein cleavage-activating protein isoform X6

    UniProtKB/Swiss-Prot
    Q12770
    Related
    ENSP00000438956.2, ENST00000545718.2
    Conserved Domains (4) summary
    COG2319
    Location:546842
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:566612
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:685842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21543
    Location:165
    MMPL; MMPL family
  4. XM_005264971.1XP_005265028.1  sterol regulatory element-binding protein cleavage-activating protein isoform X5

    See identical proteins and their annotated locations for XP_005265028.1

    Conserved Domains (4) summary
    COG2319
    Location:547843
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:567613
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:686843
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21543
    Location:165
    MMPL; MMPL family
  5. XM_005264967.2XP_005265024.1  sterol regulatory element-binding protein cleavage-activating protein isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:9381234
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:308457
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:9581004
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10771234
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_017005918.1XP_016861407.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    UniProtKB/Swiss-Prot
    Q12770
    Conserved Domains (4) summary
    COG2319
    Location:9391235
    WD40; WD40 repeat [General function prediction only]
    pfam12349
    Location:308457
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    sd00039
    Location:9591005
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10781235
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_011533502.3XP_011531804.1  sterol regulatory element-binding protein cleavage-activating protein isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:558854
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:578624
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:697854
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21543
    Location:376
    MMPL; MMPL family
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