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Scap SREBF chaperone [ Mus musculus (house mouse) ]

Gene ID: 235623, updated on 12-May-2024

Summary

Official Symbol
Scapprovided by MGI
Official Full Name
SREBF chaperoneprovided by MGI
Primary source
MGI:MGI:2135958
See related
Ensembl:ENSMUSG00000032485 AllianceGenome:MGI:2135958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0199; 9530044G19
Summary
Predicted to enable cholesterol binding activity. Acts upstream of or within several processes, including cholesterol metabolic process; regulation of lipid biosynthetic process; and response to insulin. Located in endoplasmic reticulum membrane. Is expressed in 1st branchial arch maxillary component; brain; heart; liver; and sensory organ. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 50.5), adrenal adult (RPKM 43.4) and 28 other tissues See more
Orthologs
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Genomic context

See Scap in Genome Data Viewer
Location:
9 F2; 9 59.91 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110162356..110214017)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110333288..110384949)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39429 Neighboring gene STARR-positive B cell enhancer ABC_E461 Neighboring gene microRNA 6236 Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene STARR-seq mESC enhancer starr_25259 Neighboring gene STARR-seq mESC enhancer starr_25260 Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene STARR-positive B cell enhancer ABC_E6807 Neighboring gene neutrophilic granule protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Transgenic (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sterol binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of SREBP-SCAP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sterol regulatory element-binding protein cleavage-activating protein
Names
SREBP cleavage activating protein
Sreb cleavage-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001144.3NP_001001144.2  sterol regulatory element-binding protein cleavage-activating protein

    See identical proteins and their annotated locations for NP_001001144.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC070437, BC072633, BM250223
    Consensus CDS
    CCDS23564.1
    UniProtKB/Swiss-Prot
    Q6A0A6, Q6GQT6, Q6NS67, Q7TNG7, Q80UI6
    Related
    ENSMUSP00000095953.4, ENSMUST00000098350.10
    Conserved Domains (5) summary
    smart00320
    Location:771802
    WD40; WD40 repeats
    TIGR00917
    Location:11466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:957998
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:10651232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001103162.2NP_001096632.1  sterol regulatory element-binding protein cleavage-activating protein

    See identical proteins and their annotated locations for NP_001096632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK150275, BC070437, BM250223, BY311416
    Consensus CDS
    CCDS23564.1
    UniProtKB/Swiss-Prot
    Q6A0A6, Q6GQT6, Q6NS67, Q7TNG7, Q80UI6
    Conserved Domains (5) summary
    smart00320
    Location:771802
    WD40; WD40 repeats
    TIGR00917
    Location:11466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:957998
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:10651232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001410582.1NP_001397511.1  sterol regulatory element-binding protein cleavage-activating protein

    Status: VALIDATED

    Source sequence(s)
    AC160104
    UniProtKB/Swiss-Prot
    Q6A0A6, Q6GQT6, Q6NS67, Q7TNG7, Q80UI6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110162356..110214017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512084.4XP_006512147.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    See identical proteins and their annotated locations for XP_006512147.1

    UniProtKB/Swiss-Prot
    Q6A0A6, Q6GQT6, Q6NS67, Q7TNG7, Q80UI6
    Conserved Domains (5) summary
    smart00320
    Location:771802
    WD40; WD40 repeats
    TIGR00917
    Location:11466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:957998
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:10651232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006512085.4XP_006512148.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    See identical proteins and their annotated locations for XP_006512148.1

    UniProtKB/Swiss-Prot
    Q6A0A6, Q6GQT6, Q6NS67, Q7TNG7, Q80UI6
    Conserved Domains (5) summary
    smart00320
    Location:771802
    WD40; WD40 repeats
    TIGR00917
    Location:11466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:957998
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:10651232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...