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MAPRE3 microtubule associated protein RP/EB family member 3 [ Homo sapiens (human) ]

Gene ID: 22924, updated on 4-Jul-2021

Summary

Official Symbol
MAPRE3provided by HGNC
Official Full Name
microtubule associated protein RP/EB family member 3provided by HGNC
Primary source
HGNC:HGNC:6892
See related
Ensembl:ENSG00000084764 MIM:605788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB3; RP3; EBF3; EBF3-S
Summary
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues See more
Orthologs
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Genomic context

See MAPRE3 in Genome Data Viewer
Location:
2p23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26970637..27027219)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27193505..27250087)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 2 Neighboring gene dihydropyrimidinase like 5 Neighboring gene MAPRE3 antisense RNA 1 Neighboring gene transmembrane protein 214 Neighboring gene AGBL5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein RP/EB family member 3
Names
APC binding protein
EB1 protein family member 3
end-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303050.2NP_001289979.1  microtubule-associated protein RP/EB family member 3

    See identical proteins and their annotated locations for NP_001289979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB025186, AC013472, BC011557, BM560331, HY011071
    Consensus CDS
    CCDS1731.1
    UniProtKB/Swiss-Prot
    Q9UPY8
    Conserved Domains (1) summary
    COG5217
    Location:16279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
  2. NM_012326.4NP_036458.2  microtubule-associated protein RP/EB family member 3

    See identical proteins and their annotated locations for NP_036458.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB025186, AC013472, BC011557, DC417465
    Consensus CDS
    CCDS1731.1
    UniProtKB/Swiss-Prot
    Q9UPY8
    Related
    ENSP00000233121.2, ENST00000233121.7
    Conserved Domains (1) summary
    COG5217
    Location:16279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26970637..27027219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711967.4XP_006712030.1  microtubule-associated protein RP/EB family member 3 isoform X1

    See identical proteins and their annotated locations for XP_006712030.1

    UniProtKB/Swiss-Prot
    Q9UPY8
    Related
    ENSP00000383915.3, ENST00000405074.7
    Conserved Domains (1) summary
    COG5217
    Location:16264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
  2. XM_017003597.1XP_016859086.1  microtubule-associated protein RP/EB family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9UPY8
    Conserved Domains (1) summary
    COG5217
    Location:16264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
  3. XM_011532700.1XP_011531002.1  microtubule-associated protein RP/EB family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011531002.1

    UniProtKB/Swiss-Prot
    Q9UPY8
    Related
    ENSP00000385715.1, ENST00000402218.1
    Conserved Domains (1) summary
    COG5217
    Location:16264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
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