U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARSG arylsulfatase G [ Homo sapiens (human) ]

Gene ID: 22901, updated on 2-Nov-2024

Summary

Official Symbol
ARSGprovided by HGNC
Official Full Name
arylsulfatase Gprovided by HGNC
Primary source
HGNC:HGNC:24102
See related
Ensembl:ENSG00000141337 MIM:610008; AllianceGenome:HGNC:24102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USH4
Summary
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in thyroid (RPKM 2.8), placenta (RPKM 2.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARSG in Genome Data Viewer
Location:
17q24.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68259170..68452019)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69135746..69328713)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66255311..66448160)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene solute carrier family 16 member 6 Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409262-66409920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409921-66410577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66432181-66432681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8900 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66453793-66454079 Neighboring gene microRNA 635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8902 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66494688-66494871 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66508045-66508618 Neighboring gene Sharpr-MPRA regulatory region 15560 Neighboring gene FAM20A golgi associated secretory pathway pseudokinase Neighboring gene Sharpr-MPRA regulatory region 13674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66627729-66628228 Neighboring gene long intergenic non-protein coding RNA 1482

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Usher syndrome, type 4
MedGen: C4748364 OMIM: 618144 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus?
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-sulfoglucosamine-3-sulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arylsulfatase activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
involved_in lysosome organization IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arylsulfatase G
Names
ASG
N-sulfoglucosamine-3-sulfatase
NP_001254656.1
NP_001339828.1
NP_001339829.1
NP_001339830.1
NP_001339831.1
NP_001339832.1
NP_001339833.1
NP_001339834.1
NP_001339835.1
NP_001339836.1
NP_001339838.1
NP_001339839.1
NP_055775.2
XP_011522838.1
XP_011522839.1
XP_011522848.1
XP_016879849.1
XP_016879854.1
XP_016879857.1
XP_047291588.1
XP_047291589.1
XP_047291590.1
XP_047291591.1
XP_047291592.1
XP_047291593.1
XP_047291594.1
XP_047291595.1
XP_047291596.1
XP_047291597.1
XP_047291598.1
XP_047291599.1
XP_047291600.1
XP_047291601.1
XP_047291602.1
XP_047291603.1
XP_047291604.1
XP_047291605.1
XP_047291606.1
XP_047291607.1
XP_047291608.1
XP_047291609.1
XP_047291610.1
XP_047291611.1
XP_054171473.1
XP_054171474.1
XP_054171475.1
XP_054171476.1
XP_054171477.1
XP_054171478.1
XP_054171479.1
XP_054171480.1
XP_054171481.1
XP_054171482.1
XP_054171483.1
XP_054171484.1
XP_054171485.1
XP_054171486.1
XP_054171487.1
XP_054171488.1
XP_054171489.1
XP_054171490.1
XP_054171491.1
XP_054171492.1
XP_054171493.1
XP_054171494.1
XP_054171495.1
XP_054171496.1
XP_054171497.1
XP_054171498.1
XP_054171499.1
XP_054171500.1
XP_054171501.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032814.2 RefSeqGene

    Range
    37407..166726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267727.2NP_001254656.1  arylsulfatase G isoform 1 precursor

    See identical proteins and their annotated locations for NP_001254656.1

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Related
    ENSP00000480910.1, ENST00000621439.5
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  2. NM_001352899.2NP_001339828.1  arylsulfatase G isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, CA308403
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  3. NM_001352900.2NP_001339829.1  arylsulfatase G isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BC012375
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  4. NM_001352901.2NP_001339830.1  arylsulfatase G isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BC012375
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  5. NM_001352902.2NP_001339831.1  arylsulfatase G isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, CA308403
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  6. NM_001352903.2NP_001339832.1  arylsulfatase G isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BC012375
    Conserved Domains (1) summary
    cd16161
    Location:35468
    ARSG; arylsulfatase G
  7. NM_001352904.2NP_001339833.1  arylsulfatase G isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, CA308403
    Conserved Domains (1) summary
    cd16161
    Location:35468
    ARSG; arylsulfatase G
  8. NM_001352905.2NP_001339834.1  arylsulfatase G isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BM664718
    Conserved Domains (1) summary
    cd16161
    Location:35468
    ARSG; arylsulfatase G
  9. NM_001352906.2NP_001339835.1  arylsulfatase G isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, CA308403
    Conserved Domains (1) summary
    cd16161
    Location:35468
    ARSG; arylsulfatase G
  10. NM_001352907.2NP_001339836.1  arylsulfatase G isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BC012375
    Conserved Domains (1) summary
    cd16161
    Location:35468
    ARSG; arylsulfatase G
  11. NM_001352909.2NP_001339838.1  arylsulfatase G isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780, BM664718
    Conserved Domains (1) summary
    cl23718
    Location:35420
    ALP_like; alkaline phosphatases and sulfatases
  12. NM_001352910.2NP_001339839.1  arylsulfatase G isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005332, AC007780
    Conserved Domains (1) summary
    cd16161
    Location:35436
    ARSG; arylsulfatase G
  13. NM_014960.5NP_055775.2  arylsulfatase G isoform 1 precursor

    See identical proteins and their annotated locations for NP_055775.2

    Status: REVIEWED

    Source sequence(s)
    AB023218, AC005332, AC007780, AY358380, BC012375
    Consensus CDS
    CCDS11676.1
    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Related
    ENSP00000407193.2, ENST00000448504.6
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    68259170..68452019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435644.1XP_047291600.1  arylsulfatase G isoform X7

  2. XM_047435647.1XP_047291603.1  arylsulfatase G isoform X6

  3. XM_047435645.1XP_047291601.1  arylsulfatase G isoform X7

  4. XM_047435639.1XP_047291595.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  5. XM_047435632.1XP_047291588.1  arylsulfatase G isoform X1

  6. XM_047435649.1XP_047291605.1  arylsulfatase G isoform X8

  7. XM_047435653.1XP_047291609.1  arylsulfatase G isoform X10

  8. XM_047435655.1XP_047291611.1  arylsulfatase G isoform X11

  9. XM_047435643.1XP_047291599.1  arylsulfatase G isoform X6

  10. XM_047435634.1XP_047291590.1  arylsulfatase G isoform X1

  11. XM_047435637.1XP_047291593.1  arylsulfatase G isoform X3

  12. XM_047435642.1XP_047291598.1  arylsulfatase G isoform X6

  13. XM_047435633.1XP_047291589.1  arylsulfatase G isoform X1

  14. XM_011524537.2XP_011522839.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_011522839.1

    Conserved Domains (2) summary
    COG3119
    Location:35457
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16161
    Location:35496
    ARSG; arylsulfatase G
  15. XM_011524536.3XP_011522838.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_011522838.1

    Conserved Domains (2) summary
    COG3119
    Location:35457
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16161
    Location:35496
    ARSG; arylsulfatase G
  16. XM_017024368.2XP_016879857.1  arylsulfatase G isoform X8

    Conserved Domains (2) summary
    COG3119
    Location:35354
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:35363
    ALP_like; alkaline phosphatases and sulfatases
  17. XM_047435636.1XP_047291592.1  arylsulfatase G isoform X2

  18. XM_047435641.1XP_047291597.1  arylsulfatase G isoform X5

  19. XM_047435651.1XP_047291607.1  arylsulfatase G isoform X10

  20. XM_047435652.1XP_047291608.1  arylsulfatase G isoform X11

  21. XM_047435640.1XP_047291596.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  22. XM_017024360.3XP_016879849.1  arylsulfatase G isoform X1

    Conserved Domains (2) summary
    COG3119
    Location:35457
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16161
    Location:35496
    ARSG; arylsulfatase G
  23. XM_047435648.1XP_047291604.1  arylsulfatase G isoform X8

  24. XM_047435654.1XP_047291610.1  arylsulfatase G isoform X10

  25. XM_047435646.1XP_047291602.1  arylsulfatase G isoform X7

  26. XM_047435635.1XP_047291591.1  arylsulfatase G isoform X1

  27. XM_017024365.2XP_016879854.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
    Conserved Domains (1) summary
    cd16161
    Location:35469
    ARSG; arylsulfatase G
  28. XM_047435638.1XP_047291594.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  29. XM_047435650.1XP_047291606.1  arylsulfatase G isoform X9

    UniProtKB/TrEMBL
    J9JIG6
    Related
    ENSP00000413953.2, ENST00000452479.6
  30. XM_011524546.3XP_011522848.1  arylsulfatase G isoform X12

    Conserved Domains (1) summary
    cl23718
    Location:1247
    ALP_like; alkaline phosphatases and sulfatases

RNA

  1. XR_007065287.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    69135746..69328713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315513.1XP_054171488.1  arylsulfatase G isoform X7

  2. XM_054315517.1XP_054171492.1  arylsulfatase G isoform X6

  3. XM_054315514.1XP_054171489.1  arylsulfatase G isoform X7

  4. XM_054315507.1XP_054171482.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  5. XM_054315499.1XP_054171474.1  arylsulfatase G isoform X1

  6. XM_054315518.1XP_054171493.1  arylsulfatase G isoform X8

  7. XM_054315524.1XP_054171499.1  arylsulfatase G isoform X10

  8. XM_054315526.1XP_054171501.1  arylsulfatase G isoform X11

  9. XM_054315512.1XP_054171487.1  arylsulfatase G isoform X6

  10. XM_054315503.1XP_054171478.1  arylsulfatase G isoform X1

  11. XM_054315506.1XP_054171481.1  arylsulfatase G isoform X3

  12. XM_054315511.1XP_054171486.1  arylsulfatase G isoform X6

  13. XM_054315502.1XP_054171477.1  arylsulfatase G isoform X1

  14. XM_054315501.1XP_054171476.1  arylsulfatase G isoform X1

  15. XM_054315498.1XP_054171473.1  arylsulfatase G isoform X1

  16. XM_054315516.1XP_054171491.1  arylsulfatase G isoform X8

  17. XM_054315505.1XP_054171480.1  arylsulfatase G isoform X2

  18. XM_054315510.1XP_054171485.1  arylsulfatase G isoform X5

  19. XM_054315521.1XP_054171496.1  arylsulfatase G isoform X10

  20. XM_054315522.1XP_054171497.1  arylsulfatase G isoform X11

  21. XM_054315509.1XP_054171484.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  22. XM_054315500.1XP_054171475.1  arylsulfatase G isoform X1

  23. XM_054315519.1XP_054171494.1  arylsulfatase G isoform X8

  24. XM_054315525.1XP_054171500.1  arylsulfatase G isoform X10

  25. XM_054315515.1XP_054171490.1  arylsulfatase G isoform X7

  26. XM_054315504.1XP_054171479.1  arylsulfatase G isoform X1

  27. XM_054315508.1XP_054171483.1  arylsulfatase G isoform X4

    UniProtKB/Swiss-Prot
    Q6UXF2, Q96EG1, Q9Y2K4
  28. XM_054315520.1XP_054171495.1  arylsulfatase G isoform X9

    UniProtKB/TrEMBL
    J9JIG6
  29. XM_054315523.1XP_054171498.1  arylsulfatase G isoform X12

RNA

  1. XR_008484799.1 RNA Sequence