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Psmf1 proteasome (prosome, macropain) inhibitor subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 228769, updated on 7-May-2024

Summary

Official Symbol
Psmf1provided by MGI
Official Full Name
proteasome (prosome, macropain) inhibitor subunit 1provided by MGI
Primary source
MGI:MGI:1346072
See related
Ensembl:ENSMUSG00000032869 AllianceGenome:MGI:1346072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI31
Summary
Predicted to enable proteasome binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in negative regulation of proteasomal protein catabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; lung; and nervous system. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 115.5), ovary adult (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See Psmf1 in Genome Data Viewer
Location:
2 G3; 2 74.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151557982..151586114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151716062..151744199, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAD21-like (S. pombe) Neighboring gene transmembrane 74B, opposite strand Neighboring gene transmembrane protein 74B Neighboring gene STARR-seq mESC enhancer starr_06033 Neighboring gene RIKEN cDNA 4930556L07 gene Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC18784

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome inhibitor PI31 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305244.1NP_001292173.1  proteasome inhibitor PI31 subunit isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon, and lacks two exons in the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK083431, AL928988, BE649179
    Conserved Domains (1) summary
    pfam08577
    Location:68134
    PI31_Prot_C; PI31 proteasome regulator
  2. NM_212446.2NP_997611.1  proteasome inhibitor PI31 subunit isoform 1

    See identical proteins and their annotated locations for NP_997611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK053924, AK083431, BE649179
    Consensus CDS
    CCDS16872.1
    UniProtKB/Swiss-Prot
    Q8BHL8, Q8C0G9
    UniProtKB/TrEMBL
    A2AU35, A2VCP7
    Related
    ENSMUSP00000041184.5, ENSMUST00000042452.11
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    151557982..151586114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499306.5XP_006499369.1  proteasome inhibitor PI31 subunit isoform X1

    UniProtKB/TrEMBL
    A0A1S6GWI1, A2VCP7
    Conserved Domains (2) summary
    pfam08577
    Location:193255
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:18155
    PI31_Prot_N; PI31 proteasome regulator N-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144889.2: Suppressed sequence

    Description
    NM_144889.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.