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PSMF1 proteasome inhibitor subunit 1 [ Homo sapiens (human) ]

Gene ID: 9491, updated on 7-Jun-2020

Summary

Official Symbol
PSMF1provided by HGNC
Official Full Name
proteasome inhibitor subunit 1provided by HGNC
Primary source
HGNC:HGNC:9571
See related
Ensembl:ENSG00000125818 MIM:617858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI31
Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 17.3), ovary (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See PSMF1 in Genome Data Viewer
Location:
20p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (1113229..1172246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1093872..1149017)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1111 Neighboring gene uncharacterized LOC105372494 Neighboring gene uncharacterized LOC105372493 Neighboring gene Sharpr-MPRA regulatory region 3766 Neighboring gene actin gamma 1 pseudogene 3 Neighboring gene uncharacterized LOC105372496 Neighboring gene transmembrane protein 74B Neighboring gene chromosome 20 open reading frame 202

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
proteasome core complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
proteasome inhibitor PI31 subunit
Names
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323407.2NP_001310336.1  proteasome inhibitor PI31 subunit isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA699495, AK302164, AL031665, BC126462
    UniProtKB/Swiss-Prot
    Q92530
    UniProtKB/TrEMBL
    B4DXW9
  2. NM_001323408.2NP_001310337.1  proteasome inhibitor PI31 subunit isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA699495, AL031665, DC398668
    Consensus CDS
    CCDS82589.1
    UniProtKB/TrEMBL
    Q5QPM7
    Related
    ENSP00000246015.4, ENST00000246015.8
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal
  3. NM_001323409.2NP_001310338.1  proteasome inhibitor PI31 subunit isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA699495, AL031665, DC398668
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal
  4. NM_001323410.2NP_001310339.1  proteasome inhibitor PI31 subunit isoform 6

    Status: REVIEWED

    Source sequence(s)
    AA699495, AL031665, DC398668
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal
  5. NM_006814.5NP_006805.2  proteasome inhibitor PI31 subunit isoform 1

    See identical proteins and their annotated locations for NP_006805.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA699495, AL031665, BC126127, D88378, DC398668
    Consensus CDS
    CCDS13010.1
    UniProtKB/Swiss-Prot
    Q92530
    UniProtKB/TrEMBL
    A0A140VJT2
    Related
    ENSP00000338039.6, ENST00000335877.11
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal
  6. NM_178578.3NP_848693.2  proteasome inhibitor PI31 subunit isoform 1

    See identical proteins and their annotated locations for NP_848693.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA699495, AF055032, AL031665, BC126462, DA949012, DC398121
    Consensus CDS
    CCDS13010.1
    UniProtKB/Swiss-Prot
    Q92530
    UniProtKB/TrEMBL
    A0A140VJT2
    Related
    ENSP00000327704.3, ENST00000333082.7
    Conserved Domains (2) summary
    pfam08577
    Location:182248
    PI31_Prot_C; PI31 proteasome regulator
    pfam11566
    Location:11148
    PI31_Prot_N; PI31 proteasome regulator N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    1113229..1172246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178579.1: Suppressed sequence

    Description
    NM_178579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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