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Btbd3 BTB domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 228662, updated on 17-Aug-2024

Summary

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Official Symbol
Btbd3provided by MGI
Official Full Name
BTB domain containing 3provided by MGI
Primary source
MGI:MGI:2385155
See related
Ensembl:ENSMUSG00000062098 AllianceGenome:MGI:2385155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0952
Summary
Predicted to enable identical protein binding activity. Involved in cerebral cortex development and dendrite morphogenesis. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and paravertebral ganglion. Orthologous to human BTBD3 (BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 49.2), frontal lobe adult (RPKM 24.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3; 2 68.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (138098478..138129344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (138256584..138287424)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52596 Neighboring gene predicted gene 14062 Neighboring gene STARR-seq mESC enhancer starr_05817 Neighboring gene STARR-seq mESC enhancer starr_05818 Neighboring gene STARR-seq mESC enhancer starr_05819 Neighboring gene STARR-seq mESC enhancer starr_05820 Neighboring gene STARR-seq mESC enhancer starr_05821 Neighboring gene STARR-seq mESC enhancer starr_05822 Neighboring gene STARR-seq mESC enhancer starr_05823 Neighboring gene STARR-seq mESC enhancer starr_05824 Neighboring gene predicted gene, 50497 Neighboring gene STARR-seq mESC enhancer starr_05825 Neighboring gene predicted gene, 54118

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Thompson SL, et al. Transl Psychiatry, 2019 Sep 9. PMID 31501410, Free PMC Article
  2. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. Matsui A, et al. Science, 2013 Nov 29. PMID 24179155
  3. Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem. Bechara A, et al. Cell Rep, 2015 Oct 27. PMID 26489473
  4. Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF. Sato H, et al. Elife, 2022 Mar 15. PMID 35289744, Free PMC Article
  5. Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer. Botella-López A, et al. Brain Struct Funct, 2019 Mar. PMID 30470893, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC25591

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BTB/POZ domain-containing protein 3
Names
BTB (POZ) domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025431.1 → NP_001020602.1  BTB/POZ domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001020602.1

    Status: VALIDATED

    Source sequence(s)
    AK052530, BC062968, BY012054
    Consensus CDS
    CCDS16799.1
    UniProtKB/TrEMBL
    Q3TSN9, Q8CHC1
    Related
    ENSMUSP00000089144.6, ENSMUST00000091556.12
    Conserved Domains (3) summary
    cd18348
    Location:38 → 168
    BTB_POZ_BTBD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3)
    cd18524
    Location:159 → 253
    BACK_BTBD3; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3)
    pfam08005
    Location:315 → 460
    PHR; PHR domain

  2. NM_145534.2 → NP_663509.2  BTB/POZ domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_663509.2

    Status: VALIDATED

    Source sequence(s)
    AB093275, BC062968
    Consensus CDS
    CCDS16798.1
    UniProtKB/Swiss-Prot
    P58545, Q6P5B8
    UniProtKB/TrEMBL
    Q8CHC1
    Related
    ENSMUSP00000074864.5, ENSMUST00000075410.5
    Conserved Domains (4) summary
    smart00225
    Location:129 → 228
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:234 → 340
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:121 → 224
    BTB; BTB/POZ domain
    pfam08005
    Location:385 → 528
    PHR; PHR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    138098478..138129344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250517.2 → XP_030106377.1  BTB/POZ domain-containing protein 3 isoform X1

    Conserved Domains (3) summary
    cl38908
    Location:1 → 78
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam08005
    Location:225 → 370
    PHR; PHR domain
    cl28903
    Location:69 → 163
    BACK; BACK (BTB and C-terminal Kelch) domain

  2. XM_006499294.3 → XP_006499357.1  BTB/POZ domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006499357.1

    Conserved Domains (3) summary
    cl38908
    Location:1 → 78
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam08005
    Location:225 → 370
    PHR; PHR domain
    cl28903
    Location:69 → 163
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58545.2 GenPept UniProtKB/Swiss-Prot:P58545

Gene LinkOut

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