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ATG14 autophagy related 14 [ Homo sapiens (human) ]

Gene ID: 22863, updated on 9-Jun-2019

Summary

Official Symbol
ATG14provided by HGNC
Official Full Name
autophagy related 14provided by HGNC
Primary source
HGNC:HGNC:19962
See related
Ensembl:ENSG00000126775 MIM:613515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG14L; BARKOR; KIAA0831
Expression
Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See ATG14 in Genome Data Viewer
Location:
14q22.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (55366391..55411858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55833109..55878576, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene F-box protein 34 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene uncharacterized LOC107984664 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene TATA-box binding protein like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATG14 autophagy related 14 homolog (S. cerevisiae, ATG14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
  • Nanoparticle triggered autophagic cell death, organism-specific biosystem (from WikiPathways)
    Nanoparticle triggered autophagic cell death, organism-specific biosystemProgrammed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can re...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0831, MGC126291, MGC126292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome membrane docking IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport IGI
Inferred from Genetic Interaction
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein complex stability IC
Inferred by Curator
more info
PubMed 
regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to mitochondrial depolarisation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Mitochondria-associated ER Membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extrinsic component of omegasome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site membrane TAS
Traceable Author Statement
more info
 
phosphatidylinositol 3-kinase complex, class III IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
beclin 1-associated autophagy-related key regulator
Names
ATG14 autophagy related 14 homolog
Beclin 1-Interacting protein
autophagy-related protein 14-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014924.4NP_055739.2  beclin 1-associated autophagy-related key regulator

    See identical proteins and their annotated locations for NP_055739.2

    Status: VALIDATED

    Source sequence(s)
    AA988343, AK131251, AL158801
    Consensus CDS
    CCDS32087.1
    UniProtKB/Swiss-Prot
    Q6ZNE5
    Related
    ENSP00000247178.5, ENST00000247178.5
    Conserved Domains (1) summary
    pfam10186
    Location:43388
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    55366391..55411858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536563.2XP_011534865.1  beclin 1-associated autophagy-related key regulator isoform X1

    See identical proteins and their annotated locations for XP_011534865.1

    UniProtKB/Swiss-Prot
    Q6ZNE5
    Conserved Domains (1) summary
    pfam10186
    Location:1275
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
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