Format

Send to:

Choose Destination

NTNG1 netrin G1 [ Homo sapiens (human) ]

Gene ID: 22854, updated on 17-Jun-2019

Summary

Official Symbol
NTNG1provided by HGNC
Official Full Name
netrin G1provided by HGNC
Primary source
HGNC:HGNC:23319
See related
Ensembl:ENSG00000162631 MIM:608818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lmnt1
Summary
This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
Expression
Broad expression in brain (RPKM 1.0), kidney (RPKM 0.9) and 14 other tissues See more
Orthologs

Genomic context

See NTNG1 in Genome Data Viewer
Location:
1p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (107140017..107484923)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107682540..108024477)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene protein arginine methyltransferase 6 Neighboring gene NDUFA4 pseudogene 1 Neighboring gene vav guanine nucleotide exchange factor 3 Neighboring gene microRNA 7852

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
    Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion mediator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic membrane adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
anchored component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
anchored component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin-G1
Names
axon guidance molecule
laminet 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042821.1 RefSeqGene

    Range
    5001..349982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113226.2NP_001106697.1  netrin-G1 isoform G1a preproprotein

    See identical proteins and their annotated locations for NP_001106697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (G1a).
    Source sequence(s)
    AC114491, AK025924, AY764260, AY764265, BC030220, BX538348
    Consensus CDS
    CCDS44180.1
    UniProtKB/Swiss-Prot
    Q9Y2I2
    UniProtKB/TrEMBL
    Q5IEC3, Q5IEC8
    Related
    ENSP00000359082.1, ENST00000370065.1
    Conserved Domains (3) summary
    smart00180
    Location:420467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  2. NM_001113228.2NP_001106699.1  netrin-G1 isoform G1d precursor

    See identical proteins and their annotated locations for NP_001106699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and contains two alternate exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1d) is shorter than isoform a.
    Source sequence(s)
    AC114491, AK025924, BX538348, KJ534901
    Consensus CDS
    CCDS44179.1
    UniProtKB/Swiss-Prot
    Q9Y2I2
    UniProtKB/TrEMBL
    X5DNW2
    Related
    ENSP00000359083.1, ENST00000370066.5
    Conserved Domains (3) summary
    cd00054
    Location:415439
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  3. NM_001312688.2NP_001299617.1  netrin-G1 isoform G1n precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1n) is shorter than isoform a.
    Source sequence(s)
    AC114491, AK025924, AK296533, AL513187
    UniProtKB/TrEMBL
    B4DKF0
    Conserved Domains (3) summary
    smart00180
    Location:386433
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  4. NM_001330665.2NP_001317594.1  netrin-G1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame exon and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform G1a.
    Source sequence(s)
    AC114491, AL513187, AL590427
    Consensus CDS
    CCDS81354.1
    UniProtKB/Swiss-Prot
    Q9Y2I2
    Related
    ENSP00000359084.1, ENST00000370067.5
    Conserved Domains (3) summary
    cd00054
    Location:395419
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  5. NM_014917.4NP_055732.2  netrin-G1 isoform G1c precursor

    See identical proteins and their annotated locations for NP_055732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a longer 5' UTR and lacks two exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (G1c) is shorter than isoform a.
    Source sequence(s)
    AC114491, AK025924, BC030220, DA195069
    Consensus CDS
    CCDS30785.1
    UniProtKB/Swiss-Prot
    Q9Y2I2
    Related
    ENSP00000359091.3, ENST00000370074.8
    Conserved Domains (3) summary
    cd00054
    Location:373397
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    107140017..107484923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000680.2XP_016856169.1  netrin-G1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2I2
    Related
    ENSP00000359090.2, ENST00000370073.6
    Conserved Domains (3) summary
    smart00180
    Location:420467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  2. XM_017000686.2XP_016856175.1  netrin-G1 isoform X6

    UniProtKB/Swiss-Prot
    Q9Y2I2
    Conserved Domains (2) summary
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  3. XM_017000683.2XP_016856172.1  netrin-G1 isoform X3

    UniProtKB/TrEMBL
    X5DNW2
    Related
    ENSP00000359088.2, ENST00000370071.6
    Conserved Domains (3) summary
    cd00054
    Location:415439
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  4. XM_017000681.2XP_016856170.1  netrin-G1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2I2
    Conserved Domains (3) summary
    smart00180
    Location:420467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  5. XM_017000682.2XP_016856171.1  netrin-G1 isoform X2

    Conserved Domains (4) summary
    smart00180
    Location:364411
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:418442
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  6. XM_006710456.4XP_006710519.1  netrin-G1 isoform X4

    See identical proteins and their annotated locations for XP_006710519.1

    UniProtKB/Swiss-Prot
    Q9Y2I2
    Conserved Domains (3) summary
    cd00054
    Location:373397
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  7. XM_011541025.2XP_011539327.1  netrin-G1 isoform X5

    Conserved Domains (2) summary
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  8. XM_006710455.3XP_006710518.1  netrin-G1 isoform X3

    See identical proteins and their annotated locations for XP_006710518.1

    UniProtKB/TrEMBL
    X5DNW2
    Conserved Domains (3) summary
    cd00054
    Location:415439
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
  9. XM_011541021.2XP_011539323.1  netrin-G1 isoform X1

    See identical proteins and their annotated locations for XP_011539323.1

    UniProtKB/Swiss-Prot
    Q9Y2I2
    Related
    ENSP00000359085.1, ENST00000370068.5
    Conserved Domains (3) summary
    smart00180
    Location:420467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71295
    Laminin_N; Laminin N-terminal (Domain VI)
Support Center