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ADNP2 ADNP homeobox 2 [ Homo sapiens (human) ]

Gene ID: 22850, updated on 5-Aug-2022

Summary

Official Symbol
ADNP2provided by HGNC
Official Full Name
ADNP homeobox 2provided by HGNC
Primary source
HGNC:HGNC:23803
See related
Ensembl:ENSG00000101544 MIM:617422; AllianceGenome:HGNC:23803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF508
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 13.5), testis (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

See ADNP2 in Genome Data Viewer
Location:
18q23
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (80109262..80140346)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (80385719..80416803)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77867146..77898229)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ribosome binding factor A Neighboring gene RBFA downstream neighbor Neighboring gene solute carrier family 25 member 6 pseudogene 4 Neighboring gene PARD6G antisense RNA 1 Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene uncharacterized LOC124904337

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0863

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activity-dependent neuroprotector homeobox protein 2
Names
ADNP homeobox protein 2
zinc finger protein 508

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014913.4NP_055728.1  activity-dependent neuroprotector homeobox protein 2

    See identical proteins and their annotated locations for NP_055728.1

    Status: VALIDATED

    Source sequence(s)
    AC139100, KC877689
    Consensus CDS
    CCDS32853.1
    UniProtKB/Swiss-Prot
    Q6IQ32, Q9H9P3
    UniProtKB/TrEMBL
    A0A024R377
    Related
    ENSP00000262198.3, ENST00000262198.9
    Conserved Domains (3) summary
    smart00389
    Location:10431096
    HOX; Homeodomain
    TIGR03437
    Location:465667
    Soli_cterm; Solibacter uncharacterized C-terminal domain
    pfam07793
    Location:238341
    DUF1631; Protein of unknown function (DUF1631)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    80109262..80140346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525883.3XP_011524185.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    Conserved Domains (3) summary
    smart00389
    Location:10211074
    HOX; Homeodomain
    TIGR03437
    Location:443645
    Soli_cterm; Solibacter uncharacterized C-terminal domain
    pfam07793
    Location:216319
    DUF1631; Protein of unknown function (DUF1631)
  2. XM_047437350.1XP_047293306.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

  3. XM_047437351.1XP_047293307.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

  4. XM_047437352.1XP_047293308.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    80385719..80416803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)