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Adnp2 ADNP homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 240442, updated on 26-Sep-2022

Summary

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Official Symbol
Adnp2provided by MGI
Official Full Name
ADNP homeobox 2provided by MGI
Primary source
MGI:MGI:2448562
See related
Ensembl:ENSMUSG00000053950 AllianceGenome:MGI:2448562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp508; Kiaa0863; mKIAA0863; 8430420L05Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; brain; genitourinary system; pancreas; and retina nuclear layer. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.9), placenta adult (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Adnp2 in Genome Data Viewer
Location:
18; 18 E3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80169523..80195284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80126315..80151516, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 pseudogene Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene VISTA enhancer mm1711 Neighboring gene predicted gene, 41787 Neighboring gene phosphoglycerate mutase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the adnp2 may have an important function in brain by playing a role in cellular survival pathways.
    Title: Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38953

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
activity-dependent neuroprotector homeobox protein 2
Names
ADNP homeobox protein 2
zinc finger protein 508

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175028.1 → NP_778193.1  activity-dependent neuroprotector homeobox protein 2

    See identical proteins and their annotated locations for NP_778193.1

    Status: VALIDATED

    Source sequence(s)
    AB093268, BC024969
    Consensus CDS
    CCDS50332.1
    UniProtKB/Swiss-Prot
    Q8CHC8, Q8R1A2
    Related
    ENSMUSP00000068560.9, ENSMUST00000066743.11
    Conserved Domains (3) summary
    smart00389
    Location:1082 → 1126
    HOX; Homeodomain
    PHA03247
    Location:268 → 695
    PHA03247; large tegument protein UL36; Provisional
    pfam18868
    Location:907 → 970
    zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80169523..80195284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526466.4 → XP_006526529.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006526529.1

    UniProtKB/Swiss-Prot
    Q8CHC8, Q8R1A2
    Conserved Domains (3) summary
    smart00389
    Location:1082 → 1126
    HOX; Homeodomain
    PHA03247
    Location:268 → 695
    PHA03247; large tegument protein UL36; Provisional
    pfam18868
    Location:907 → 970
    zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

  2. XM_036161143.1 → XP_036017036.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

    Conserved Domains (2) summary
    smart00389
    Location:978 → 1022
    HOX; Homeodomain
    PHA03247
    Location:164 → 591
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHC8.2 GenPept UniProtKB/Swiss-Prot:Q8CHC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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