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P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 [ Mus musculus (house mouse) ]

Gene ID: 228139, updated on 12-Mar-2024

Summary

Official Symbol
P2rx3provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 3provided by MGI
Primary source
MGI:MGI:1097160
See related
Ensembl:ENSMUSG00000027071 AllianceGenome:MGI:1097160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2X3; 4930513E20Rik
Summary
Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.8), CNS E14 (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

Location:
2 D; 2 49.45 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84826893..84867446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84996549..85037108, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 2, bone marrow Neighboring gene proteoglycan 3 Neighboring gene structure specific recognition protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene tankyrase 1 binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC28163

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in behavioral response to formalin induced pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral response to pain IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to ATP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ATP IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to carbohydrate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of taste IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within urinary bladder smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within urinary bladder smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
P2X purinoceptor 3
Names
ATP receptor
purinergic receptor P2X3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145526.3NP_663501.2  P2X purinoceptor 3

    See identical proteins and their annotated locations for NP_663501.2

    Status: VALIDATED

    Source sequence(s)
    AL935159
    Consensus CDS
    CCDS16200.1
    UniProtKB/Swiss-Prot
    A2AW02, Q3UR32, Q8R1U4
    UniProtKB/TrEMBL
    A2AW04
    Related
    ENSMUSP00000028465.8, ENSMUST00000028465.14
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84826893..84867446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499210.5XP_006499273.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006499273.1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  2. XM_030250185.2XP_030106045.1  P2X purinoceptor 3 isoform X1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  3. XM_011239452.3XP_011237754.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011237754.1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  4. XM_030250183.2XP_030106043.1  P2X purinoceptor 3 isoform X1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  5. XM_030250184.2XP_030106044.1  P2X purinoceptor 3 isoform X1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  6. XM_030250186.2XP_030106046.1  P2X purinoceptor 3 isoform X1

    UniProtKB/TrEMBL
    A2AW04
    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor