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P2RX3 purinergic receptor P2X 3 [ Homo sapiens (human) ]

Gene ID: 5024, updated on 3-Jun-2018
Official Symbol
P2RX3provided by HGNC
Official Full Name
purinergic receptor P2X 3provided by HGNC
Primary source
HGNC:HGNC:8534
See related
Ensembl:ENSG00000109991 MIM:600843; Vega:OTTHUMG00000167025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2X3
Summary
This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
Expression
Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues See more
Orthologs
See P2RX3 in Genome Data Viewer
Location:
11q12.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (57335943..57372399)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57105841..57137549)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tankyrase 1 binding protein 1 Neighboring gene structure specific recognition protein 1 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene proteoglycan 2, pro eosinophil major basic protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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  • Elevation of cytosolic Ca2+ levels, organism-specific biosystem (from REACTOME)
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  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
    Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
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  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC129956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
ATP-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
extracellularly ATP-gated cation channel activity NAS
Non-traceable Author Statement
more info
PubMed 
purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purinergic nucleotide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
purinergic nucleotide receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
behavioral response to formalin induced pain IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monovalent inorganic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
peristalsis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport into cytosol NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of calcium-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
urinary bladder smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
P2X purinoceptor 3
Names
ATP receptor
P2X receptor, subunit 3
purinergic receptor P2X, ligand gated ion channel, 3
purinergic receptor P2X3
purinoceptor P2X3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002559.4NP_002550.2  P2X purinoceptor 3

    See identical proteins and their annotated locations for NP_002550.2

    Status: REVIEWED

    Source sequence(s)
    AP000781, BC069162, BC074792, BM677534, DB462670, HY032450
    Consensus CDS
    CCDS7953.1
    UniProtKB/Swiss-Prot
    P56373
    Related
    ENSP00000263314.2, OTTHUMP00000234771, ENST00000263314.2
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    57335943..57372399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545070.2XP_011543372.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543372.1

    UniProtKB/Swiss-Prot
    P56373
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  2. XM_011545069.2XP_011543371.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543371.1

    UniProtKB/Swiss-Prot
    P56373
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  3. XM_011545071.2XP_011543373.1  P2X purinoceptor 3 isoform X2

    Conserved Domains (1) summary
    pfam00864
    Location:8361
    P2X_receptor; ATP P2X receptor
  4. XM_011545072.2XP_011543374.1  P2X purinoceptor 3 isoform X3

    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  5. XM_011545073.1XP_011543375.1  P2X purinoceptor 3 isoform X4

    Conserved Domains (1) summary
    cl02993
    Location:1199
    P2X_receptor; ATP P2X receptor

RNA

  1. XR_949950.2 RNA Sequence

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