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P2RX3 purinergic receptor P2X 3 [ Homo sapiens (human) ]

Gene ID: 5024, updated on 5-Jan-2022

Summary

Official Symbol
P2RX3provided by HGNC
Official Full Name
purinergic receptor P2X 3provided by HGNC
Primary source
HGNC:HGNC:8534
See related
Ensembl:ENSG00000109991 MIM:600843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2X3
Summary
This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
Expression
Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues See more
Orthologs
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Genomic context

See P2RX3 in Genome Data Viewer
Location:
11q12.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57335943..57372399)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57105826..57139869)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tankyrase 1 binding protein 1 Neighboring gene structure specific recognition protein 1 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene proteoglycan 2, pro eosinophil major basic protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129956

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in behavioral response to formalin induced pain IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in peristalsis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion transport into cytosol NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in urinary bladder smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
P2X purinoceptor 3
Names
ATP receptor
P2X receptor, subunit 3
purinergic receptor P2X, ligand gated ion channel, 3
purinergic receptor P2X3
purinoceptor P2X3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002559.5NP_002550.2  P2X purinoceptor 3

    See identical proteins and their annotated locations for NP_002550.2

    Status: REVIEWED

    Source sequence(s)
    AP000781, BC069162, BC074792, DB462670, HY032450
    Consensus CDS
    CCDS7953.1
    UniProtKB/Swiss-Prot
    P56373
    Related
    ENSP00000263314.2, ENST00000263314.3
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57335943..57372399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545070.2XP_011543372.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543372.1

    UniProtKB/Swiss-Prot
    P56373
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  2. XM_011545069.2XP_011543371.1  P2X purinoceptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011543371.1

    UniProtKB/Swiss-Prot
    P56373
    Conserved Domains (1) summary
    pfam00864
    Location:8363
    P2X_receptor; ATP P2X receptor
  3. XM_011545071.2XP_011543373.1  P2X purinoceptor 3 isoform X2

    Conserved Domains (1) summary
    pfam00864
    Location:8361
    P2X_receptor; ATP P2X receptor
  4. XM_011545072.2XP_011543374.1  P2X purinoceptor 3 isoform X3

    Conserved Domains (1) summary
    pfam00864
    Location:1289
    P2X_receptor; ATP P2X receptor
  5. XM_011545073.1XP_011543375.1  P2X purinoceptor 3 isoform X4

    Conserved Domains (1) summary
    cl02993
    Location:1199
    P2X_receptor; ATP P2X receptor

RNA

  1. XR_949950.2 RNA Sequence

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