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Cytip cytohesin 1 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 227929, updated on 12-May-2024

Summary

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Official Symbol
Cytipprovided by MGI
Official Full Name
cytohesin 1 interacting proteinprovided by MGI
Primary source
MGI:MGI:2183535
See related
Ensembl:ENSMUSG00000026832 AllianceGenome:MGI:2183535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbp; Cybr; Pscdbp; A130053M09Rik
Summary
Predicted to be involved in regulation of cell adhesion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cell cortex. Is expressed in metanephros. Orthologous to human CYTIP (cytohesin 1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.2), spleen adult (RPKM 14.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Cytip in Genome Data Viewer
Location:
2 C1.1; 2 33.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (58019151..58085559, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58129139..58195549, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04539 Neighboring gene ermin, ERM-like protein Neighboring gene polypeptide N-acetylgalactosaminyltransferase 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57882224-57882524 Neighboring gene STARR-seq mESC enhancer starr_04540 Neighboring gene STARR-positive B cell enhancer ABC_E3374 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2036 Neighboring gene STARR-positive B cell enhancer ABC_E1589 Neighboring gene STARR-positive B cell enhancer ABC_E3375 Neighboring gene STARR-positive B cell enhancer ABC_E5917 Neighboring gene STARR-positive B cell enhancer ABC_E5918 Neighboring gene STARR-positive B cell enhancer ABC_E7817 Neighboring gene STARR-positive B cell enhancer ABC_E5919 Neighboring gene STARR-positive B cell enhancer ABC_E3376 Neighboring gene STARR-seq mESC enhancer starr_04541 Neighboring gene predicted gene 13546 Neighboring gene STARR-positive B cell enhancer mm9_chr2:58049102-58049403 Neighboring gene STARR-seq mESC enhancer starr_04542 Neighboring gene STARR-positive B cell enhancer mm9_chr2:58134871-58135172 Neighboring gene activin A receptor, type IC Neighboring gene predicted gene 13544 Neighboring gene 60S ribosomal protein L29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytip regulates dendritic-cell function in contact hypersensitivity. Heib V, et al. Eur J Immunol, 2012 Mar. PMID 22488362, Free PMC Article
  2. Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation. Watford WT, et al. Mol Cell Biol, 2006 Sep. PMID 16914744, Free PMC Article
  3. The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Coppola V, et al. Mol Cell Biol, 2006 Jul. PMID 16809763, Free PMC Article
  4. A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer. Gorski KS, et al. Mol Immunol, 2003 Sep. PMID 12909129
  5. GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. Martinez-Garcia M, et al. PLoS Genet, 2023 Feb. PMID 36809245, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest a suppressive function for Cytip in mouse dendritic cells in limiting immune responses.
    Title: Cytip regulates dendritic-cell function in contact hypersensitivity.
  2. Cybr represses the expression of T-bet and IFN-gamma via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice.
    Title: Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and host immunity.
  3. These data suggest that Cybr is not absolutely required for hematopoietic cell development or function, but stem cells lacking Cybr are at a developmental disadvantage compared to wild-type cells.
    Title: Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.
  4. expression in vivo is differentially modulated by type 1 cytokines during lymphocyte maturation
    Title: The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytohesin-interacting protein
Names
cbp HE
cytohesin binding protein
cytohesin-binding protein HE
pleckstrin homology, Sec7 and coiled-coil domains, binding protein
tamalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139200.4 → NP_631939.1  cytohesin-interacting protein

    See identical proteins and their annotated locations for NP_631939.1

    Status: VALIDATED

    Source sequence(s)
    AK152784, AK157859, AL928564
    Consensus CDS
    CCDS16048.1
    UniProtKB/Swiss-Prot
    A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9
    UniProtKB/TrEMBL
    Q3TCC3, Q3TLX8
    Related
    ENSMUSP00000028175.7, ENSMUST00000028175.7
    Conserved Domains (1) summary
    cd00992
    Location:76 → 161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    58019151..58085559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498012.5 → XP_006498075.1  cytohesin-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006498075.1

    UniProtKB/Swiss-Prot
    A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9
    UniProtKB/TrEMBL
    Q3TCC3, Q3TLX8
    Conserved Domains (1) summary
    cd00992
    Location:76 → 161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. XM_006498013.3 → XP_006498076.1  cytohesin-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006498076.1

    UniProtKB/Swiss-Prot
    A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9
    UniProtKB/TrEMBL
    Q3TCC3, Q3TLX8
    Conserved Domains (1) summary
    cd00992
    Location:76 → 161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VY6.1 GenPept UniProtKB/Swiss-Prot:Q91VY6

Gene LinkOut

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