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CYTIP cytohesin 1 interacting protein [ Homo sapiens (human) ]

Gene ID: 9595, updated on 21-Apr-2019

Summary

Official Symbol
CYTIPprovided by HGNC
Official Full Name
cytohesin 1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:9506
See related
Ensembl:ENSG00000115165 MIM:604448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HE; B3-1; CASP; CYBR; CYTHIP; PSCDBP
Summary
The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
Expression
Biased expression in lymph node (RPKM 28.7), bone marrow (RPKM 27.5) and 11 other tissues See more
Orthologs

Genomic context

See CYTIP in Genome Data Viewer
Location:
2q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (157412782..157444092, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (158271131..158300604, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 133, member A pseudogene Neighboring gene uncharacterized LOC105373711 Neighboring gene uncharacterized LOC105373712 Neighboring gene activin A receptor type 1C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytohesin-interacting protein
Names
cbp HE
cytohesin binder and regulator
cytohesin binding protein HE
cytohesin-associated scaffolding protein
pleckstrin homology Sec7 and coiled-coil domains-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004288.5NP_004279.3  cytohesin-interacting protein

    See identical proteins and their annotated locations for NP_004279.3

    Status: REVIEWED

    Source sequence(s)
    AC019201, BC036449, DB219691
    Consensus CDS
    CCDS2204.1
    UniProtKB/Swiss-Prot
    O60759
    Related
    ENSP00000264192.3, ENST00000264192.8
    Conserved Domains (1) summary
    cd00992
    Location:76161
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    157412782..157444092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005386.2XP_016860875.1  cytohesin-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    O60759
    Conserved Domains (1) summary
    cd00992
    Location:555
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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