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Zic1 zinc finger protein of the cerebellum 1 [ Mus musculus (house mouse) ]

Gene ID: 22771, updated on 8-Feb-2024

Summary

Official Symbol
Zic1provided by MGI
Official Full Name
zinc finger protein of the cerebellum 1provided by MGI
Primary source
MGI:MGI:106683
See related
Ensembl:ENSMUSG00000032368 AllianceGenome:MGI:106683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIC; ZNF201
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including central nervous system development; positive regulation of protein import into nucleus; and regulation of smoothened signaling pathway. Acts upstream of or within adult walking behavior and central nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; metanephros; and visual system. Used to study Dandy-Walker syndrome and Joubert syndrome. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 92.7), whole brain E14.5 (RPKM 45.5) and 4 other tissues See more
Orthologs
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Genomic context

See Zic1 in Genome Data Viewer
Location:
9 E3.2; 9 48.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (91240111..91250136, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (91358058..91365768, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730094K22 gene Neighboring gene methionyl aminopeptidase 1 pseudogene Neighboring gene predicted gene, 40546 Neighboring gene predicted gene, 40545 Neighboring gene zinc finger protein of the cerebellum 4 Neighboring gene predicted gene 29478 Neighboring gene predicted gene, 39400

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in maintenance of cell number IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in olfactory bulb development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pattern specification process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of smoothened signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein ZIC 1
Names
Zic family member 1 (odd-paired homolog, Drosophila)
odd-paired homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376941.1NP_001363870.1  zinc finger protein ZIC 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC116582, AK141431, BC060247, CD741655
    UniProtKB/Swiss-Prot
    P46684, Q6PAK5, Q80Y18
    UniProtKB/TrEMBL
    Q3TWA9
    Related
    ENSMUSP00000068858.4, ENSMUST00000065360.5
    Conserved Domains (3) summary
    COG5189
    Location:298382
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:276296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:219264
    zf_ZIC; Zic proteins zinc finger domain
  2. NM_009573.4NP_033599.2  zinc finger protein ZIC 1

    See identical proteins and their annotated locations for NP_033599.2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK141431, BC063247, BY261991, CD741655, CN666056
    Consensus CDS
    CCDS23403.1
    UniProtKB/Swiss-Prot
    P46684, Q6PAK5, Q80Y18
    UniProtKB/TrEMBL
    Q3TWA9
    Related
    ENSMUSP00000034927.7, ENSMUST00000034927.13
    Conserved Domains (3) summary
    COG5189
    Location:298382
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:276296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:219264
    zf_ZIC; Zic proteins zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    91240111..91250136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154847.1XP_036010740.1  zinc finger protein ZIC 1 isoform X1

    UniProtKB/Swiss-Prot
    P46684, Q6PAK5, Q80Y18
    UniProtKB/TrEMBL
    Q3TWA9
    Conserved Domains (3) summary
    COG5189
    Location:298382
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:276296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:219264
    zf_ZIC; Zic proteins zinc finger domain