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Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha [ Mus musculus (house mouse) ]

Gene ID: 226849, updated on 11-Apr-2024

Summary

Official Symbol
Ppp2r5aprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', alphaprovided by MGI
Primary source
MGI:MGI:2388479
See related
Ensembl:ENSMUSG00000026626 AllianceGenome:MGI:2388479
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR61alpha
Summary
Predicted to enable kinase binding activity; phosphoprotein phosphatase activity; and protein phosphatase activator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; protein dephosphorylation; and regulation of phosphate metabolic process. Located in M band and Z disc. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and neural retina. Orthologous to human PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 92.3), subcutaneous fat pad adult (RPKM 91.4) and 27 other tissues See more
Orthologs
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Genomic context

See Ppp2r5a in Genome Data Viewer
Location:
1 H6; 1 96.28 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191084178..191129238, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191351981..191397041, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuron derived neurotrophic factor Neighboring gene STARR-positive B cell enhancer ABC_E7787 Neighboring gene proton activated chloride channel 1 Neighboring gene STARR-positive B cell enhancer ABC_E10076 Neighboring gene RAB11B, member RAS oncogene family, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E7788 Neighboring gene STARR-positive B cell enhancer ABC_E177 Neighboring gene STARR-positive B cell enhancer ABC_E998 Neighboring gene poly(A) binding protein, nuclear 1 pseudogene Neighboring gene predicted gene, 31987 Neighboring gene predicted gene, 32128

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38798

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144880.4NP_659129.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

    See identical proteins and their annotated locations for NP_659129.2

    Status: PROVISIONAL

    Source sequence(s)
    AC115896, AC124664
    Consensus CDS
    CCDS15620.1
    UniProtKB/Swiss-Prot
    Q6PD03, Q8R1U7
    UniProtKB/TrEMBL
    Q3ULN8
    Related
    ENSMUSP00000070726.4, ENSMUST00000067976.9
    Conserved Domains (2) summary
    PLN00122
    Location:351466
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:64461
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191084178..191129238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)