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PPP2R5A protein phosphatase 2 regulatory subunit B'alpha [ Homo sapiens (human) ]

Gene ID: 5525, updated on 13-Mar-2020

Summary

Official Symbol
PPP2R5Aprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'alphaprovided by HGNC
Primary source
HGNC:HGNC:9309
See related
Ensembl:ENSG00000066027 MIM:601643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56A; PR61A; B56alpha
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in fat (RPKM 41.9), lung (RPKM 33.2) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R5A in Genome Data Viewer
Location:
1q32.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (212285410..212361853)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212458879..212535205)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene denticleless E3 ubiquitin protein ligase homolog Neighboring gene RN7SK pseudogene 98 Neighboring gene long intergenic non-protein coding RNA 2608 Neighboring gene uncharacterized LOC107985262 Neighboring gene ribosomal protein L23a pseudogene 18 Neighboring gene small nucleolar RNA, H/ACA box 16B Neighboring gene proton activated chloride channel 1 Neighboring gene uncharacterized LOC105372906 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11595

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vif vif HIV-1 Vif degrades PPP2R5A in CEM-T4 T cells PubMed
vif HIV-1 Vif binds PPP2R5A expression in CEM-T4 T cells PubMed
vif HIV-1 Vif downregulates PPP2R5A expression in a Cul5 dependent manner in CEM-T4 T cells PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
capsid gag The interaction of HIV-1 CA with human cellular protein phosphatase 2, regulatory subunit B', alpha (PPP2R5A) is identified by yeast two-hybrid screen PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131915

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of lipid kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
M band ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Names
PP2A B subunit isoform B'-alpha
PP2A B subunit isoform B56-alpha
PP2A B subunit isoform PR61-alpha
PP2A B subunit isoform R5-alpha
PP2A, B subunit, B' alpha isoform
PP2A, B subunit, B56 alpha isoform
PP2A, B subunit, PR61 alpha isoform
PP2A, B subunit, R5 alpha isoform
PR61alpha
protein phosphatase 2 regulatory subunit B', alpha
protein phosphatase 2, regulatory subunit B (B56), alpha isoform
protein phosphatase 2, regulatory subunit B', alpha isoform
serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199756.2NP_001186685.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 2

    See identical proteins and their annotated locations for NP_001186685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK302202, BP326450, L42373
    Consensus CDS
    CCDS55686.1
    UniProtKB/Swiss-Prot
    Q15172
    Related
    ENSP00000442866.1, ENST00000537030.3
    Conserved Domains (1) summary
    pfam01603
    Location:4385
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_006243.4NP_006234.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_006234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL451060, L42373
    Consensus CDS
    CCDS1503.1
    UniProtKB/Swiss-Prot
    Q15172
    Related
    ENSP00000261461.2, ENST00000261461.7
    Conserved Domains (1) summary
    pfam01603
    Location:61442
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    212285410..212361853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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