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Sf1 splicing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 22668, updated on 3-Apr-2024

Summary

Official Symbol
Sf1provided by MGI
Official Full Name
splicing factor 1provided by MGI
Primary source
MGI:MGI:1095403
See related
Ensembl:ENSMUSG00000024949 AllianceGenome:MGI:1095403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BBP; MZFM; WBP4; Zfp162
Summary
Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: SF1 (Gene ID: 22668) and NR5A1 (Gene ID: 26423) share the SF1 symbol/alias in common. SF1 is a widely used alternative name for nuclear receptor subfamily 5 group A member 1 (NR5A1), which can be confused with the official symbol for SF1 (splicing factor 1). [30 Mar 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 49.7), adrenal adult (RPKM 41.6) and 28 other tissues See more
Orthologs
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Genomic context

See Sf1 in Genome Data Viewer
Location:
19 A; 19 4.48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6413952..6428060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6363673..6378038)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene predicted gene, 57665 Neighboring gene muscle glycogen phosphorylase Neighboring gene STARR-positive B cell enhancer ABC_E4263 Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of U2AF complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
splicing factor 1
Names
mammalian branch point-binding protein
transcription factor ZFM1
zinc finger gene in MEN1 locus
zinc finger protein 162

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110791.2NP_001104261.1  splicing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001104261.1

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Consensus CDS
    CCDS50368.1
    UniProtKB/TrEMBL
    Q3UI45, Q3UK67
    Related
    ENSMUSP00000121309.2, ENSMUST00000131252.8
    Conserved Domains (2) summary
    smart00343
    Location:278293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
  2. NM_001360393.2NP_001347322.1  splicing factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Conserved Domains (1) summary
    cl25681
    Location:29211
    SF1-HH; Splicing factor 1 helix-hairpin domain
  3. NM_001403434.1NP_001390363.1  splicing factor 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  4. NM_001403435.1NP_001390364.1  splicing factor 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  5. NM_001403436.1NP_001390365.1  splicing factor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  6. NM_001403439.1NP_001390368.1  splicing factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  7. NM_001403440.1NP_001390369.1  splicing factor 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    UniProtKB/TrEMBL
    D3YZC9
    Related
    ENSMUSP00000109117.2, ENSMUST00000113489.8
  8. NM_001403441.1NP_001390370.1  splicing factor 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  9. NM_001403442.1NP_001390371.1  splicing factor 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  10. NM_001403443.1NP_001390372.1  splicing factor 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  11. NM_001403444.1NP_001390373.1  splicing factor 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  12. NM_001403445.1NP_001390374.1  splicing factor 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Conserved Domains (2) summary
    smart00343
    Location:278293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
  13. NM_001403446.1NP_001390375.1  splicing factor 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  14. NM_001403447.1NP_001390376.1  splicing factor 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  15. NM_001403448.1NP_001390377.1  splicing factor 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
  16. NM_001403449.1NP_001390378.1  splicing factor 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    UniProtKB/TrEMBL
    D3YZD0
    Related
    ENSMUSP00000109116.2, ENSMUST00000113488.8
  17. NM_011750.3NP_035880.2  splicing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_035880.2

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Consensus CDS
    CCDS50369.1
    UniProtKB/TrEMBL
    E9Q4Q2, Q3TZI3
    Related
    ENSMUSP00000109115.2, ENSMUST00000113487.8
    Conserved Domains (2) summary
    smart00343
    Location:278293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6413952..6428060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_122118.1: Suppressed sequence

    Description
    NR_122118.1: This RefSeq was removed because it is now thought that this gene does encode a protein.