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Sf1 splicing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 22668, updated on 15-Aug-2019

Summary

Official Symbol
Sf1provided by MGI
Official Full Name
splicing factor 1provided by MGI
Primary source
MGI:MGI:1095403
See related
Ensembl:ENSMUSG00000024949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BBP; MZFM; WBP4; Zfp162
Expression
Ubiquitous expression in thymus adult (RPKM 49.7), adrenal adult (RPKM 41.6) and 28 other tissues See more
Orthologs

Genomic context

See Sf1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6363673..6378038)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6363690..6378038)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene U7 small nuclear RNA Neighboring gene predicted gene 14966 Neighboring gene muscle glycogen phosphorylase Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
pre-mRNA branch point binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Leydig cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
male sex determination IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
nuclear body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of steroid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
splicing factor 1
Names
mammalian branch point-binding protein
transcription factor ZFM1
zinc finger gene in MEN1 locus
zinc finger protein 162

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110791.1NP_001104261.1  splicing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001104261.1

    Status: VALIDATED

    Source sequence(s)
    AA122547, AK147081, AV255405, BX523718, CJ175598
    Consensus CDS
    CCDS50368.1
    UniProtKB/TrEMBL
    Q3UI45
    Related
    ENSMUSP00000121309.1, ENSMUST00000131252.7
    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  2. NM_001360393.1NP_001347322.1  splicing factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Conserved Domains (1) summary
    cl25681
    Location:29211
    SF1-HH; Splicing factor 1 helix-hairpin domain
  3. NM_011750.2NP_035880.2  splicing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_035880.2

    Status: VALIDATED

    Source sequence(s)
    AA122547, AK157845, AV255405, BX523718, CD563870, CJ175598
    Consensus CDS
    CCDS50369.1
    UniProtKB/TrEMBL
    E9Q4Q2, Q3TZI3
    Related
    ENSMUSP00000109115.1, ENSMUST00000113487.7
    Conserved Domains (2) summary
    smart00343
    Location:278293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

RNA

  1. NR_122118.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167245, AK152914, AV255405, CJ175598

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p6 C57BL/6J

    Range
    6363673..6378038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531734.4XP_006531797.1  splicing factor 1 isoform X3

    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  2. XM_006531737.4XP_006531800.1  splicing factor 1 isoform X9

    UniProtKB/TrEMBL
    D3YZC9
    Related
    ENSMUSP00000109117.1, ENSMUST00000113489.7
    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  3. XM_006531735.4XP_006531798.1  splicing factor 1 isoform X4

    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  4. XM_006531738.4XP_006531801.1  splicing factor 1 isoform X10

    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  5. XM_006531740.4XP_006531803.1  splicing factor 1 isoform X14

    UniProtKB/TrEMBL
    D3YZD0
    Related
    ENSMUSP00000109116.1, ENSMUST00000113488.7
    Conserved Domains (3) summary
    smart00343
    Location:278293
    ZnF_C2HC; zinc finger
    cd02395
    Location:137255
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16275
    Location:18130
    SF1-HH; Splicing factor 1 helix-hairpin domain
  6. XM_006531736.2XP_006531799.1  splicing factor 1 isoform X7

    Conserved Domains (3) summary
    smart00343
    Location:232247
    ZnF_C2HC; zinc finger
    cd02395
    Location:91209
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16275
    Location:2784
    SF1-HH; Splicing factor 1 helix-hairpin domain
  7. XM_030250931.1XP_030106791.1  splicing factor 1 isoform X13

  8. XM_030250930.1XP_030106790.1  splicing factor 1 isoform X12

  9. XM_006531733.4XP_006531796.1  splicing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006531796.1

    Conserved Domains (1) summary
    cl25681
    Location:17257
    SF1-HH; Splicing factor 1 helix-hairpin domain
  10. XM_030250925.1XP_030106785.1  splicing factor 1 isoform X5

  11. XM_030250926.1XP_030106786.1  splicing factor 1 isoform X6

  12. XM_030250929.1XP_030106789.1  splicing factor 1 isoform X11

  13. XM_030250928.1XP_030106788.1  splicing factor 1 isoform X8

  14. XM_030250923.1XP_030106783.1  splicing factor 1 isoform X2

  15. XM_030250927.1XP_030106787.1  splicing factor 1 isoform X7

Reference GRCm38.p6 PATCHES

Genomic

  1. NW_012132910.1 Reference GRCm38.p6 PATCHES

    Range
    180607..194955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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