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FGG fibrinogen gamma chain [ Homo sapiens (human) ]

Gene ID: 2266, updated on 4-May-2020

Summary

Official Symbol
FGGprovided by HGNC
Official Full Name
fibrinogen gamma chainprovided by HGNC
Primary source
HGNC:HGNC:3694
See related
Ensembl:ENSG00000171557 MIM:134850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward liver (RPKM 3614.5) See more
Orthologs

Genomic context

See FGG in Genome Data Viewer
Location:
4q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (154604134..154612808, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (155525286..155533902, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene fibrinogen beta chain Neighboring gene fibrinogen alpha chain Neighboring gene VISTA enhancer hs1706 Neighboring gene VISTA enhancer hs1707 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Afibrinogenemia, congenital
MedGen: C2584774 OMIM: 202400 GeneReviews: Not available
Compare labs
Dysfibrinogenemia, congenital
MedGen: C0272350 OMIM: 616004 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
NHGRI GWA Catalog
Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.
NHGRI GWA Catalog
Genetic predictors of fibrin D-dimer levels in healthy adults.
NHGRI GWA Catalog
Genetics of venous thrombosis: insights from a new genome wide association study.
NHGRI GWA Catalog
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
extracellular matrix structural constituent HDA PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation, fibrin clot formation IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-6 IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
platelet maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptide hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
fibrinogen complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibrinogen gamma chain
Names
fibrinogen, gamma polypeptide
testicular tissue protein Li 70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008834.1 RefSeqGene

    Range
    4943..13617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000509.5NP_000500.2  fibrinogen gamma chain isoform gamma-A precursor

    See identical proteins and their annotated locations for NP_000500.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma-A) is the predominant transcript and is shorter than variant gamma-B. Variant gamma-A encodes isoform gamma-A, which is shorter and has a distinct C-terminus compared to isoform gamma-B.
    Source sequence(s)
    AW014527, BC021674, BX382942
    Consensus CDS
    CCDS47153.1
    UniProtKB/Swiss-Prot
    P02679
    UniProtKB/TrEMBL
    A0A140VJJ6
    Related
    ENSP00000384860.3, ENST00000404648.7
    Conserved Domains (2) summary
    cl00085
    Location:175414
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:31172
    Fib_alpha; Fibrinogen alpha/beta chain family
  2. NM_021870.3NP_068656.2  fibrinogen gamma chain isoform gamma-B precursor

    See identical proteins and their annotated locations for NP_068656.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma-B) represents the longer transcript and encodes the longer isoform (gamma-B).
    Source sequence(s)
    AC107385, AI808530, AL531173, BC007044, BG567044
    Consensus CDS
    CCDS3788.1
    UniProtKB/Swiss-Prot
    P02679
    Related
    ENSP00000336829.3, ENST00000336098.8
    Conserved Domains (2) summary
    pfam08702
    Location:31172
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:175414
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    154604134..154612808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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