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Fgg fibrinogen gamma chain [ Mus musculus (house mouse) ]

Gene ID: 99571, updated on 8-Dec-2022

Summary

Official Symbol
Fggprovided by MGI
Official Full Name
fibrinogen gamma chainprovided by MGI
Primary source
MGI:MGI:95526
See related
Ensembl:ENSMUSG00000033860 AllianceGenome:MGI:95526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3010002H13Rik
Summary
This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
Expression
Biased expression in liver E18 (RPKM 2199.8), liver adult (RPKM 856.8) and 3 other tissues See more
Orthologs
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Genomic context

See Fgg in Genome Data Viewer
Location:
3 E3; 3 36.94 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82915031..82922363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83007724..83015056)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 46 Neighboring gene RNA binding motif protein 46, opposite strand Neighboring gene lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) Neighboring gene predicted gene, 30097 Neighboring gene predicted gene, 40075 Neighboring gene fibrinogen alpha chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in blood microparticle ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibrinogen gamma chain
Names
fibrinogen, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317105.1NP_001304034.1  fibrinogen gamma chain isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138394, AK149375, AW113409, BY793963
    Consensus CDS
    CCDS84633.1
    UniProtKB/TrEMBL
    Q3UER8
    Related
    ENSMUSP00000141648.2, ENSMUST00000194175.2
    Conserved Domains (2) summary
    pfam08702
    Location:30171
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:174413
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_133862.2NP_598623.1  fibrinogen gamma chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_598623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC138394, AK149448, BP772517, BY793963
    Consensus CDS
    CCDS38462.1
    UniProtKB/Swiss-Prot
    Q8VCM7, Q91ZP0
    UniProtKB/TrEMBL
    Q3UEM7
    Related
    ENSMUSP00000037018.8, ENSMUST00000048486.13
    Conserved Domains (2) summary
    pfam08702
    Location:30171
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:174413
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    82915031..82922363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)