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Prrc2c proline-rich coiled-coil 2C [ Mus musculus (house mouse) ]

Gene ID: 226562, updated on 2-Nov-2024

Summary

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Official Symbol
Prrc2cprovided by MGI
Official Full Name
proline-rich coiled-coil 2Cprovided by MGI
Primary source
MGI:MGI:1913754
See related
Ensembl:ENSMUSG00000040225 AllianceGenome:MGI:1913754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bat2d; Prrc3; Bat2d1; Bat2l2; mKIAA1096; A630006J20; 1810043M20Rik; 9630039I18Rik; E130112L15Rik
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; lung; and main olfactory bulb. Orthologous to human PRRC2C (proline rich coiled-coil 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 26.1), limb E14.5 (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prrc2c in Genome Data Viewer
Location:
1 H2.1; 1 70.3 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162499354..162568125, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162671785..162740560, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin Neighboring gene myocilin opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene flavin containing monooxygenase 4 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene flavin containing monooxygenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Representational difference analysis of cDNA of genes expressed in embryonic kidney. Wada J, et al. Kidney Int, 1997 May. PMID 9150484
  2. PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Zhang Y, et al. Cell Rep, 2024 Mar 26. PMID 38507412
  3. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Piniella D, et al. Cell Mol Life Sci, 2021 Dec. PMID 34709416, Free PMC Article
  4. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
  5. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein PRRC2C
Names
BAT2 domain containing 1
BAT2 domain-containing protein 1
HLA-B-associated transcript 2-like 2
proline-rich and coiled-coil-containing protein 2C
protein BAT2-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081290.1 → NP_001074759.1  protein PRRC2C

    See identical proteins and their annotated locations for NP_001074759.1

    Status: PROVISIONAL

    Source sequence(s)
    AC118643, AC132867
    Consensus CDS
    CCDS35749.1
    UniProtKB/Swiss-Prot
    E9QKG5, Q05CS4, Q05DM5, Q3TKF3, Q3TLH4, Q3UXU5, Q4FZE4, Q66K03, Q6P3F4, Q80TK3, Q80YR0, Q8BMJ4, Q8C1K7, Q8CGH3
    Related
    ENSMUSP00000138433.2, ENSMUST00000182660.8
    Conserved Domains (2) summary
    pfam03153
    Location:2331 → 2534
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162499354..162568125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320026.3 → XP_017175515.1  protein PRRC2C isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  2. XM_006496771.5 → XP_006496834.1  protein PRRC2C isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  3. XM_006496772.5 → XP_006496835.1  protein PRRC2C isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  4. XM_006496766.5 → XP_006496829.1  protein PRRC2C isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  5. XM_006496770.5 → XP_006496833.1  protein PRRC2C isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  6. XM_011238785.4 → XP_011237087.1  protein PRRC2C isoform X12

    UniProtKB/TrEMBL
    S4R294
    Related
    ENSMUSP00000138548.2, ENSMUST00000182149.8
    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  7. XM_011238784.4 → XP_011237086.1  protein PRRC2C isoform X9

    See identical proteins and their annotated locations for XP_011237086.1

    UniProtKB/Swiss-Prot
    Q3TLH4
    Conserved Domains (2) summary
    PHA03247
    Location:1707 → 1979
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  8. XM_006496769.5 → XP_006496832.1  protein PRRC2C isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:1700 → 1972
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 155
    BAT2_N; BAT2 N-terminus

  9. XM_006496767.5 → XP_006496830.1  protein PRRC2C isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:1705 → 1977
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

  10. XM_011238788.4 → XP_011237090.1  protein PRRC2C isoform X10

    UniProtKB/TrEMBL
    S4R2J9
    Related
    ENSMUSP00000138674.2, ENSMUST00000182593.8
    Conserved Domains (2) summary
    PHA03247
    Location:1705 → 1977
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

  11. XM_011238787.4 → XP_011237089.1  protein PRRC2C isoform X4

    UniProtKB/TrEMBL
    A0A0A0MQ79
    Related
    ENSMUSP00000028016.10, ENSMUST00000028016.16
    Conserved Domains (2) summary
    PHA03247
    Location:1705 → 1977
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

  12. XM_006496768.5 → XP_006496831.1  protein PRRC2C isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:1702 → 1974
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 157
    BAT2_N; BAT2 N-terminus

  13. XM_011238786.4 → XP_011237088.1  protein PRRC2C isoform X13

    Conserved Domains (2) summary
    PHA03247
    Location:371 → 443
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025603.1: Suppressed sequence

    Description
    NM_025603.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TLH4.3 GenPept UniProtKB/Swiss-Prot:Q3TLH4

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