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Zranb3 zinc finger, RAN-binding domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 226409, updated on 12-May-2024

Summary

Official Symbol
Zranb3provided by MGI
Official Full Name
zinc finger, RAN-binding domain containing 3provided by MGI
Primary source
MGI:MGI:1918362
See related
Ensembl:ENSMUSG00000036086 AllianceGenome:MGI:1918362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AH2; C730006D09; 4933425L19Rik
Summary
Predicted to enable ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Predicted to be involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 1.7), limb E14.5 (RPKM 1.0) and 24 other tissues See more
Orthologs
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Genomic context

See Zranb3 in Genome Data Viewer
Location:
1 E3; 1 55.8 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127881916..128030799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127954179..128103053, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:129726872-129727109 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E7742 Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene predicted gene 28800 Neighboring gene STARR-seq mESC enhancer starr_02154 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129912788-129913088 Neighboring gene My020 protein Neighboring gene STARR-seq mESC enhancer starr_02156 Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129973654-129973955 Neighboring gene STARR-positive B cell enhancer ABC_E991 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129999606-129999907 Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene R3H domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02158 Neighboring gene microRNA 128-1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA rewinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork reversal ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA annealing helicase and endonuclease ZRANB3
Names
annealing helicase 2
zinc finger Ran-binding domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285945.1NP_001272874.1  DNA annealing helicase and endonuclease ZRANB3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131995, AK016921, BC066035
    UniProtKB/Swiss-Prot
    Q6NZP1
    UniProtKB/TrEMBL
    Q9D3Z7
    Conserved Domains (6) summary
    smart00547
    Location:625647
    ZnF_RBZ; Zinc finger domain
    smart00487
    Location:33216
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:59194
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00085
    Location:9781043
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:625644
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00271
    Location:334439
    Helicase_C; Helicase conserved C-terminal domain
  2. NM_001357573.1NP_001344502.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC129545, AC131995
    Consensus CDS
    CCDS35697.1
    UniProtKB/Swiss-Prot
    Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6
    Related
    ENSMUSP00000108157.3, ENSMUST00000112538.4
    Conserved Domains (4) summary
    smart00547
    Location:621643
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:7477
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:9741039
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:621640
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  3. NM_027678.3NP_081954.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

    See identical proteins and their annotated locations for NP_081954.1

    Status: VALIDATED

    Source sequence(s)
    AC129545, AC131995, AK084943, BC066035
    Consensus CDS
    CCDS35697.1
    UniProtKB/Swiss-Prot
    Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6
    Related
    ENSMUSP00000083806.6, ENSMUST00000086614.12
    Conserved Domains (4) summary
    smart00547
    Location:621643
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:7477
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:9741039
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:621640
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    127881916..128030799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529408.2XP_006529471.1  DNA annealing helicase and endonuclease ZRANB3 isoform X1

    Conserved Domains (5) summary
    smart00547
    Location:625647
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:11481
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:10251090
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:625644
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:41260
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  2. XM_036163815.1XP_036019708.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:561583
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:1417
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:9611026
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:561580
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:1196
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  3. XM_006529411.5XP_006529474.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

    See identical proteins and their annotated locations for XP_006529474.1

    Conserved Domains (5) summary
    smart00547
    Location:621643
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:7477
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:10211086
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:621640
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:37256
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  4. XM_006529410.2XP_006529473.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

    See identical proteins and their annotated locations for XP_006529473.1

    Conserved Domains (5) summary
    smart00547
    Location:621643
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:7477
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:10211086
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:621640
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:37256
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  5. XM_036163817.1XP_036019710.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:561583
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:1417
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:9611026
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:561580
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:1196
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  6. XM_030253114.1XP_030108974.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:561583
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:1417
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:9611026
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:561580
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:1196
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  7. XM_006529409.1XP_006529472.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

    See identical proteins and their annotated locations for XP_006529472.1

    Conserved Domains (5) summary
    smart00547
    Location:621643
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:7477
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:10211086
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:621640
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:37256
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  8. XM_030253115.1XP_030108975.1  DNA annealing helicase and endonuclease ZRANB3 isoform X4

    Conserved Domains (5) summary
    smart00547
    Location:561583
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:1417
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:914979
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:561580
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:1196
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
  9. XM_036163819.1XP_036019712.1  DNA annealing helicase and endonuclease ZRANB3 isoform X5

    Conserved Domains (4) summary
    smart00547
    Location:290312
    ZnF_RBZ; Zinc finger domain
    cd00085
    Location:690755
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:290309
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18793
    Location:9115
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
  10. XM_006529416.3XP_006529479.1  DNA annealing helicase and endonuclease ZRANB3 isoform X6

    See identical proteins and their annotated locations for XP_006529479.1

    UniProtKB/TrEMBL
    Q8BUI4, Q9D3Z7
    Conserved Domains (2) summary
    COG0553
    Location:11481
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18010
    Location:41260
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

RNA

  1. XR_001784077.2 RNA Sequence

  2. XR_004941832.1 RNA Sequence