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ZRANB3 zinc finger RANBP2-type containing 3 [ Homo sapiens (human) ]

Gene ID: 84083, updated on 22-Aug-2021

Summary

Official Symbol
ZRANB3provided by HGNC
Official Full Name
zinc finger RANBP2-type containing 3provided by HGNC
Primary source
HGNC:HGNC:25249
See related
Ensembl:ENSG00000121988 MIM:615655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AH2; 4933425L19Rik
Expression
Broad expression in testis (RPKM 1.8), thyroid (RPKM 0.8) and 24 other tissues See more
Orthologs
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Genomic context

See ZRANB3 in Genome Data Viewer
Location:
2q21.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (135196969..135531218, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135954539..136288788, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene HNF4 motif-containing MPRA enhancer 203 Neighboring gene small nucleolar RNA, H/ACA box 40B Neighboring gene Sharpr-MPRA regulatory region 5980 Neighboring gene G3BP1 pseudogene 1 Neighboring gene R3H domain containing 1 Neighboring gene RNA, U6 small nuclear 512, pseudogene Neighboring gene microRNA 128-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75012, MGC105033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA/DNA annealing activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA rewinding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in replication fork processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in replication fork protection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in replication fork protection IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to UV IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
DNA annealing helicase and endonuclease ZRANB3
Names
annealing helicase 2
zinc finger Ran-binding domain-containing protein 3
zinc finger, RAN-binding domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286568.2NP_001273497.1  DNA annealing helicase and endonuclease ZRANB3 isoform 2

    See identical proteins and their annotated locations for NP_001273497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC017031, AI670931, BX647838
    Consensus CDS
    CCDS67963.1
    UniProtKB/Swiss-Prot
    Q5FWF4
    Related
    ENSP00000383979.1, ENST00000401392.5
    Conserved Domains (6) summary
    cd00046
    Location:55190
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00085
    Location:10091047
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:625644
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00176
    Location:40316
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:330435
    Helicase_C; Helicase conserved C-terminal domain
    pfam00641
    Location:625647
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. NM_001286569.1NP_001273498.1  DNA annealing helicase and endonuclease ZRANB3 isoform 3

    See identical proteins and their annotated locations for NP_001273498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC016742, AC017031, AC064850, AI670931, AL833322
    Consensus CDS
    CCDS74580.1
    UniProtKB/TrEMBL
    F5GYN7
    Related
    ENSP00000441320.2, ENST00000536680.5
    Conserved Domains (3) summary
    cd00085
    Location:557595
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:171190
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:171193
    zf-RanBP; Zn-finger in Ran binding protein and others
  3. NM_032143.4NP_115519.2  DNA annealing helicase and endonuclease ZRANB3 isoform 1

    See identical proteins and their annotated locations for NP_115519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform 1.
    Source sequence(s)
    AC017031, AI670931, BC089429
    Consensus CDS
    CCDS46419.1
    UniProtKB/Swiss-Prot
    Q5FWF4
    Related
    ENSP00000264159.6, ENST00000264159.11
    Conserved Domains (6) summary
    cd00046
    Location:55190
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00085
    Location:10111049
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:625644
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00176
    Location:40316
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:330435
    Helicase_C; Helicase conserved C-terminal domain
    pfam00641
    Location:625647
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    135196969..135531218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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