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Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22631, updated on 14-May-2024

Summary

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Official Symbol
Ywhazprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideprovided by MGI
Primary source
MGI:MGI:109484
See related
Ensembl:ENSMUSG00000022285 AllianceGenome:MGI:109484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
14-3-3zeta; 1110013I11Rik
Summary
Enables protein domain specific binding activity. Involved in several processes, including respiratory system process; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of cell death. Located in hippocampal mossy fiber to CA3 synapse and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 171.9), cortex adult (RPKM 135.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ywhaz in Genome Data Viewer
Location:
15 B3.1; 15 14.56 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36770505..36803228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36770261..36802984, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41296 Neighboring gene STARR-positive B cell enhancer ABC_E5473 Neighboring gene STARR-positive B cell enhancer mm9_chr15:36649081-36649381 Neighboring gene RIKEN cDNA A830021M18 gene Neighboring gene predicted gene, 41297 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36681031-36681268 Neighboring gene STARR-seq mESC enhancer starr_38374 Neighboring gene STARR-seq mESC enhancer starr_38375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36724178-36724450 Neighboring gene predicted gene, 41298 Neighboring gene predicted gene, 34472 Neighboring gene STARR-seq mESC enhancer starr_38379 Neighboring gene predicted gene, 41299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function. Oppong AK, et al. Am J Physiol Endocrinol Metab, 2020 Jul 1. PMID 32369418
  2. 14-3-3ζ loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Joshi S, et al. Am J Cancer Res, 2017. PMID 28861322, Free PMC Article
  3. Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells. Liu Q, et al. Curr Eye Res, 2017 Aug. PMID 28494163
  4. 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Schoenwaelder SM, et al. Nat Commun, 2016 Sep 27. PMID 27670677, Free PMC Article
  5. Ywhaz/14-3-3ζ Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism. Lim GE, et al. Endocrinology, 2016 Jul. PMID 27167773

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3zeta.
    Title: IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ.
  2. High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
    Title: High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
  3. 14-3-3zeta inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis.
    Title: 14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis.
  4. YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m[6]A-mediated YWHAZ stability.
    Title: YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m(6)A-mediated YWHAZ stability.
  5. 14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells.
    Title: 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells.
  6. Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis.
    Title: Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
  7. 14-3-3zeta mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.
    Title: 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.
  8. Reducing 14-3-3zeta expression influences adipocyte maturity and impairs function.
    Title: Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function.
  9. It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain.
    Title: Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain.
  10. DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
    Title: Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (3) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi reassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
  
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic target recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tube formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
14-3-3 protein zeta/delta
Names
14-3-3 zeta
KCIP-1
SEZ-2
protein kinase C inhibitor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253805.1 → NP_001240734.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, AK083368, BB652039, BC050891, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1
    Related
    ENSMUSP00000105990.2, ENSMUST00000110361.8
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  2. NM_001253806.1 → NP_001240735.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, BC050891, BQ833188, CF172373
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  3. NM_001253807.1 → NP_001240736.1  14-3-3 protein zeta/delta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138604
    Conserved Domains (1) summary
    cl02098
    Location:1 → 209
    14-3-3; 14-3-3 domain

  4. NM_001356569.1 → NP_001343498.1  14-3-3 protein zeta/delta isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  5. NM_011740.3 → NP_035870.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_035870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604, AK150381, BB652039, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1
    Related
    ENSMUSP00000022894.8, ENSMUST00000022894.14
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    36770505..36803228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248527.2 → XP_030104387.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1
    Related
    ENSMUSP00000105991.4, ENSMUST00000110362.4
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63101.1 GenPept UniProtKB/Swiss-Prot:P63101

Gene LinkOut

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