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Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22631, updated on 21-Jul-2020

Summary

Official Symbol
Ywhazprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideprovided by MGI
Primary source
MGI:MGI:109484
See related
Ensembl:ENSMUSG00000022285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI596267; AL022924; AU020854; 14-3-3zeta; 1110013I11Rik
Expression
Ubiquitous expression in frontal lobe adult (RPKM 171.9), cortex adult (RPKM 135.4) and 28 other tissues See more
Orthologs

Genomic context

See Ywhaz in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
9
Annotation release Status Assembly Chr Location
108.20200622 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36770261..36802984, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (36700016..36724293, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41296 Neighboring gene RIKEN cDNA A830021M18 gene Neighboring gene predicted gene, 41297 Neighboring gene predicted gene, 41298 Neighboring gene predicted gene, 34472 Neighboring gene predicted gene, 41299

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi reassembly ISO
Inferred from Sequence Orthology
more info
 
establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
synaptic target recognition IDA
Inferred from Direct Assay
more info
PubMed 
synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein zeta/delta
Names
14-3-3 zeta
KCIP-1
SEZ-2
protein kinase C inhibitor protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253805.1NP_001240734.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, AK083368, BB652039, BC050891, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101
    Related
    ENSMUSP00000105990.1, ENSMUST00000110361.7
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  2. NM_001253806.1NP_001240735.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, BC050891, BQ833188, CF172373
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  3. NM_001253807.1NP_001240736.1  14-3-3 protein zeta/delta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138604
    Conserved Domains (1) summary
    cl02098
    Location:1209
    14-3-3; 14-3-3 domain
  4. NM_001356569.1NP_001343498.1  14-3-3 protein zeta/delta isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604
    Consensus CDS
    CCDS27432.1
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  5. NM_011740.3NP_035870.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_035870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604, AK150381, BB652039, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101
    Related
    ENSMUSP00000022894.7, ENSMUST00000022894.13
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: Mus musculus Updated Annotation Release 108.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

    Range
    36770261..36802984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248527.1XP_030104387.1  14-3-3 protein zeta/delta isoform X1

    Related
    ENSMUSP00000105991.3, ENSMUST00000110362.3
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