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Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22631, updated on 9-Mar-2023

Summary

Official Symbol
Ywhazprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideprovided by MGI
Primary source
MGI:MGI:109484
See related
Ensembl:ENSMUSG00000022285 AllianceGenome:MGI:109484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
14-3-3zeta; 1110013I11Rik
Summary
Enables protein domain specific binding activity. Involved in several processes, including respiratory system process; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of cell death. Located in hippocampal mossy fiber to CA3 synapse and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 171.9), cortex adult (RPKM 135.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ywhaz in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36770505..36803228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36770261..36802984, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41296 Neighboring gene RIKEN cDNA A830021M18 gene Neighboring gene predicted gene, 41297 Neighboring gene predicted gene, 41298 Neighboring gene predicted gene, 34472 Neighboring gene predicted gene, 41299

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Golgi reassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic target recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tube formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein zeta/delta
Names
14-3-3 zeta
KCIP-1
SEZ-2
protein kinase C inhibitor protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253805.1NP_001240734.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, AK083368, BB652039, BC050891, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101, Q5EBQ1
    UniProtKB/TrEMBL
    A0A6P7QG65, A0A8C6H8F6
    Related
    ENSMUSP00000105990.2, ENSMUST00000110361.8
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  2. NM_001253806.1NP_001240735.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_001240735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AA277102, AK003664, BC050891, BQ833188, CF172373
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101, Q5EBQ1
    UniProtKB/TrEMBL
    A0A6P7QG65, A0A8C6H8F6
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  3. NM_001253807.1NP_001240736.1  14-3-3 protein zeta/delta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138604
    Conserved Domains (1) summary
    cl02098
    Location:1209
    14-3-3; 14-3-3 domain
  4. NM_001356569.1NP_001343498.1  14-3-3 protein zeta/delta isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    Q5EBQ1
    UniProtKB/TrEMBL
    A0A6P7QG65, A0A8C6H8F6
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  5. NM_011740.3NP_035870.1  14-3-3 protein zeta/delta isoform 1

    See identical proteins and their annotated locations for NP_035870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 and 5 encode the same isoform 1.
    Source sequence(s)
    AC138604, AK150381, BB652039, BQ833188
    Consensus CDS
    CCDS27432.1
    UniProtKB/Swiss-Prot
    P63101, Q5EBQ1
    UniProtKB/TrEMBL
    A0A6P7QG65, A0A8C6H8F6
    Related
    ENSMUSP00000022894.8, ENSMUST00000022894.14
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    36770505..36803228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248527.2XP_030104387.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    Q5EBQ1
    UniProtKB/TrEMBL
    A0A6P7QG65, A0A8C6H8F6
    Related
    ENSMUSP00000105991.4, ENSMUST00000110362.4
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein