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YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [ Homo sapiens (human) ]

Gene ID: 7534, updated on 9-Feb-2020

Summary

Official Symbol
YWHAZprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaprovided by HGNC
Primary source
HGNC:HGNC:12855
See related
Ensembl:ENSG00000164924 MIM:601288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in esophagus (RPKM 248.0), brain (RPKM 160.0) and 25 other tissues See more
Orthologs

Genomic context

See YWHAZ in Genome Data Viewer
Location:
8q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (100916523..100954068, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101930804..101965717, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr8.2573 Neighboring gene ribosomal protein S26 pseudogene 6 Neighboring gene RNA, 7SL, cytoplasmic 685, pseudogene Neighboring gene uncharacterized LOC401471

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ) in Jurkat cells PubMed
Vpr vpr BiFC assays demonstrate that 14-3-3 zeta directly interacts with HIV-1 Vpr in the nulceus of HeLa cells PubMed
vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3-zeta (YWHAZ) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111427, MGC126532, MGC138156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
establishment of Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
synaptic target recognition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
14-3-3 protein zeta/delta
Names
14-3-3 delta
14-3-3 protein/cytosolic phospholipase A2
14-3-3 zeta
epididymis luminal protein 4
epididymis secretory protein Li 3
epididymis secretory protein Li 93
phospholipase A2
protein kinase C inhibitor protein-1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135699.1NP_001129171.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AA830489, BC072426, BM783874
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000398599.1, ENST00000457309.2
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  2. NM_001135700.2NP_001129172.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, CR996247
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379286.3, ENST00000395956.7
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  3. NM_001135701.2NP_001129173.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, CN276627, CR996247
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000395114.2, ENST00000419477.6
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  4. NM_001135702.2NP_001129174.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, BQ605329, DB472116
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379281.3, ENST00000395951.7
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  5. NM_003406.4NP_003397.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_003397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, DC298291
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000309503.3, ENST00000353245.7
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  6. NM_145690.3NP_663723.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_663723.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379288.2, ENST00000395958.6
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    100916523..100954068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251061.3XP_005251118.1  14-3-3 protein zeta/delta isoform X1

    See identical proteins and their annotated locations for XP_005251118.1

    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  2. XM_017013810.2XP_016869299.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  3. XM_017013811.1XP_016869300.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  4. XM_024447266.1XP_024303034.1  14-3-3 protein zeta/delta isoform X1

    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  5. XM_005251063.3XP_005251120.1  14-3-3 protein zeta/delta isoform X1

    See identical proteins and their annotated locations for XP_005251120.1

    UniProtKB/Swiss-Prot
    P63104
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379283.2, ENST00000395953.6
    Conserved Domains (1) summary
    cd10022
    Location:2230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  6. XM_011517290.2XP_011515592.1  14-3-3 protein zeta/delta isoform X2

  7. XM_017013812.1XP_016869301.1  14-3-3 protein zeta/delta isoform X3

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