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YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [ Homo sapiens (human) ]

Gene ID: 7534, updated on 29-Mar-2023

Summary

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Official Symbol
YWHAZprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaprovided by HGNC
Primary source
HGNC:HGNC:12855
See related
Ensembl:ENSG00000164924 MIM:601288; AllianceGenome:HGNC:12855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in esophagus (RPKM 248.0), brain (RPKM 160.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See YWHAZ in Genome Data Viewer
Location:
8q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (100916523..100953382, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (102042222..102079082, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101928751..101965610, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:101912042-101913241 Neighboring gene ribosomal protein S26 pseudogene 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101962627-101963486 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:101964345-101965203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101969053-101969554 Neighboring gene RNA, 7SL, cytoplasmic 685, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease. Yin S, et al. Oxid Med Cell Longev, 2022. PMID 36199425, Free PMC Article
  2. YWHAZ variation causes intellectual disability and global developmental delay with brain malformation. Wan RP, et al. Hum Mol Genet, 2023 Jan 13. PMID 36001342, Free PMC Article
  3. Overexpression of 14-3-3ζ primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC. Wei L, et al. Aging (Albany NY), 2022 Jul 22. PMID 35876652, Free PMC Article
  4. Quantitation of Human 14-3-3ζ Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria. Trošanová Z, et al. J Mol Biol, 2022 Apr 15. PMID 35134439
  5. Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein. T S S, et al. Proteins, 2022 May. PMID 35006623

See all (690) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.
    Title: YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.
  2. Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma.
    Title: Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma.
  3. hucMSC-sEVs-Derived 14-3-3zeta Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease.
    Title: hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease.
  4. Overexpression of 14-3-3zeta primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC.
    Title: Overexpression of 14-3-3ζ primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC.
  5. Quantitation of Human 14-3-3zeta Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria.
    Title: Quantitation of Human 14-3-3ζ Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria.
  6. TBP, PPIA, YWHAZ and EF1A1 Are the Most Stably Expressed Genes during Osteogenic Differentiation.
    Title: TBP, PPIA, YWHAZ and EF1A1 Are the Most Stably Expressed Genes during Osteogenic Differentiation.
  7. Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis.
    Title: Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
  8. Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3zeta protein.
    Title: Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein.
  9. PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14-3-3zeta/Akt signalling pathway.
    Title: PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14-3-3zeta/Akt signalling pathway.
  10. CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
    Title: CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
Submit: New GeneRIF Correction See all GeneRIFs (190)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ) in Jurkat cells PubMed
Vpr vpr BiFC assays demonstrate that 14-3-3 zeta directly interacts with HIV-1 Vpr in the nulceus of HeLa cells PubMed
vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3-zeta (YWHAZ) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111427, MGC126532, MGC138156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoserine residue binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi reassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of Golgi localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory system process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IEA
Inferred from Electronic Annotation
more info
  
involved_in tube formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in vesicle HDA PubMed 

General protein information

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Preferred Names
14-3-3 protein zeta/delta
Names
14-3-3 delta
14-3-3 protein/cytosolic phospholipase A2
14-3-3 zeta
epididymis luminal protein 4
epididymis secretory protein Li 3
epididymis secretory protein Li 93
phospholipase A2
protein kinase C inhibitor protein-1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135699.2 → NP_001129171.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AA830489, AC018781, AC027373, BC072426, BM783874
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000398599.1, ENST00000457309.2
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  2. NM_001135700.2 → NP_001129172.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, CR996247
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379286.3, ENST00000395956.7
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  3. NM_001135701.2 → NP_001129173.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, CN276627, CR996247
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000395114.2, ENST00000419477.6
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  4. NM_001135702.2 → NP_001129174.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_001129174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, BQ605329, DB472116
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379281.3, ENST00000395951.7
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  5. NM_003406.4 → NP_003397.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_003397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874, DC298291
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000309503.3, ENST00000353245.7
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  6. NM_145690.3 → NP_663723.1  14-3-3 protein zeta/delta

    See identical proteins and their annotated locations for NP_663723.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. All six transcripts encode the same protein.
    Source sequence(s)
    AC027373, BC072426, BM783874
    Consensus CDS
    CCDS6290.1
    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379288.2, ENST00000395958.6
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    100916523..100953382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013810.3 → XP_016869299.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  2. XM_005251061.4 → XP_005251118.1  14-3-3 protein zeta/delta isoform X1

    See identical proteins and their annotated locations for XP_005251118.1

    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379287.2, ENST00000395957.6
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  3. XM_017013811.2 → XP_016869300.1  14-3-3 protein zeta/delta isoform X1

    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  4. XM_005251063.4 → XP_005251120.1  14-3-3 protein zeta/delta isoform X1

    See identical proteins and their annotated locations for XP_005251120.1

    UniProtKB/Swiss-Prot
    P63104, Q86V33
    UniProtKB/TrEMBL
    D0PNI1
    Related
    ENSP00000379283.2, ENST00000395953.6
    Conserved Domains (1) summary
    cd10022
    Location:2 → 230
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    102042222..102079082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361182.1 → XP_054217157.1  14-3-3 protein zeta/delta isoform X1

  2. XM_054361184.1 → XP_054217159.1  14-3-3 protein zeta/delta isoform X1

  3. XM_054361185.1 → XP_054217160.1  14-3-3 protein zeta/delta isoform X1

  4. XM_054361183.1 → XP_054217158.1  14-3-3 protein zeta/delta isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63104.1 GenPept UniProtKB/Swiss-Prot:P63104

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