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Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22627, updated on 8-Jan-2023

Summary

Official Symbol
Ywhaeprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideprovided by MGI
Primary source
MGI:MGI:894689
See related
Ensembl:ENSMUSG00000020849 AllianceGenome:MGI:894689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein domain specific binding activity and protein phosphatase binding activity. Acts upstream of or within several processes, including negative regulation of protein dephosphorylation; neuron migration; and pallium development. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 424.9), CNS E18 (RPKM 417.5) and 25 other tissues See more
Orthologs
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Genomic context

See Ywhae in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75620121..75656667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75732887..75765841)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin IC Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene uncharacterized LOC118567335 Neighboring gene double C2, beta Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in central region of growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein epsilon
Names
14-3-3 epsilon
14-3-3E
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009536.4NP_033562.3  14-3-3 protein epsilon

    See identical proteins and their annotated locations for NP_033562.3

    Status: VALIDATED

    Source sequence(s)
    AK135831, BC058686, BY293945
    Consensus CDS
    CCDS25056.1
    UniProtKB/Swiss-Prot
    P62259
    UniProtKB/TrEMBL
    A0A6P5QPV5, A0A8C6HYG3, Q5SS40
    Related
    ENSMUSP00000070993.4, ENSMUST00000067664.10
    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75620121..75656667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156631.1XP_036012524.1  14-3-3 protein epsilon isoform X1

    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein