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Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22627, updated on 9-Dec-2018

Summary

Official Symbol
Ywhaeprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideprovided by MGI
Primary source
MGI:MGI:894689
See related
Ensembl:ENSMUSG00000020849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU019196
Expression
Broad expression in CNS E11.5 (RPKM 424.9), CNS E18 (RPKM 417.5) and 25 other tissues See more
Orthologs

Genomic context

See Ywhae in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (75732887..75765841)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75546389..75579343)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene myosin IC Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene double C2, beta Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
central region of growth cone ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
kinesin complex ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein epsilon
Names
14-3-3 epsilon
14-3-3E
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009536.4NP_033562.3  14-3-3 protein epsilon

    See identical proteins and their annotated locations for NP_033562.3

    Status: VALIDATED

    Source sequence(s)
    AK135831, BC058686, BY293945
    Consensus CDS
    CCDS25056.1
    UniProtKB/Swiss-Prot
    P62259
    UniProtKB/TrEMBL
    Q5SS40
    Related
    ENSMUSP00000070993.3, ENSMUST00000067664.9
    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    75732887..75765841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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