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Afap1l2 actin filament associated protein 1-like 2 [ Mus musculus (house mouse) ]

Gene ID: 226250, updated on 26-Sep-2022

Summary

Official Symbol
Afap1l2provided by MGI
Official Full Name
actin filament associated protein 1-like 2provided by MGI
Primary source
MGI:MGI:2147658
See related
Ensembl:ENSMUSG00000025083 AllianceGenome:MGI:2147658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1914
Summary
Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and nervous system. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 15.2), cerebellum adult (RPKM 10.4) and 21 other tissues See more
Orthologs
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Genomic context

See Afap1l2 in Genome Data Viewer
Location:
19; 19 D2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56900786..57017021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56912354..57028589, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene predicted gene, 38597 Neighboring gene actin-binding LIM protein 1 Neighboring gene RIKEN cDNA 4930449E18 gene Neighboring gene RIKEN cDNA B230217O12 gene Neighboring gene predicted gene, 50270

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1914, MGC28084

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin filament-associated protein 1-like 2
Names
AFAP1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177796.1NP_001171267.1  actin filament-associated protein 1-like 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant encodes the longest isoform (1).
    Source sequence(s)
    AC125150, AC161518, AK087449, BB064561, BB849668
    Consensus CDS
    CCDS50477.1
    UniProtKB/Swiss-Prot
    Q5DTU0
    Related
    ENSMUSP00000107210.3, ENSMUST00000111584.9
    Conserved Domains (3) summary
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:371471
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:189288
    PH; PH domain
  2. NM_001177797.1NP_001171268.1  actin filament-associated protein 1-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001171268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC161518, AK220430, BB064561, BB849668
    Consensus CDS
    CCDS50476.1
    UniProtKB/Swiss-Prot
    Q5DTU0, Q8K2G0
    Related
    ENSMUSP00000113745.2, ENSMUST00000118800.8
    Conserved Domains (3) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:171270
    PH; PH domain
  3. NM_146102.2NP_666214.1  actin filament-associated protein 1-like 2 isoform 3

    See identical proteins and their annotated locations for NP_666214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125150, AC161518, AK048649, BB064561, BB849668
    Consensus CDS
    CCDS29924.1
    UniProtKB/Swiss-Prot
    Q5DTU0
    UniProtKB/TrEMBL
    A0A0R4J1L6
    Related
    ENSMUSP00000112387.2, ENSMUST00000122359.8
    Conserved Domains (4) summary
    cd13306
    Location:109215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    TIGR02169
    Location:593709
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    NF033201
    Location:424578
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56900786..57017021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161574.1XP_036017467.1  actin filament-associated protein 1-like 2 isoform X4

    Conserved Domains (4) summary
    PRK03918
    Location:695799
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:192298
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:399499
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:526680
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  2. XM_036161572.1XP_036017465.1  actin filament-associated protein 1-like 2 isoform X1

    Conserved Domains (4) summary
    PRK03918
    Location:714818
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:211317
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:418518
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:545699
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  3. XM_036161573.1XP_036017466.1  actin filament-associated protein 1-like 2 isoform X2

    Conserved Domains (4) summary
    PRK03918
    Location:696800
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:400500
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:527681
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  4. XM_036161577.1XP_036017470.1  actin filament-associated protein 1-like 2 isoform X7

    Conserved Domains (4) summary
    PRK03918
    Location:640744
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:137243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:344444
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:471625
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  5. XM_036161575.1XP_036017468.1  actin filament-associated protein 1-like 2 isoform X5

    Conserved Domains (4) summary
    PRK03918
    Location:686790
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:390490
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:517671
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
  6. XM_036161576.1XP_036017469.1  actin filament-associated protein 1-like 2 isoform X6

    Conserved Domains (4) summary
    PHA03369
    Location:489823
    PHA03369; capsid maturational protease; Provisional
    PRK03918
    Location:668772
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:372472
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
  7. XM_006527024.3XP_006527087.1  actin filament-associated protein 1-like 2 isoform X3

    Conserved Domains (4) summary
    PHA03369
    Location:516850
    PHA03369; capsid maturational protease; Provisional
    PRK03918
    Location:695799
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:211317
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:399499
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
  8. XM_036161579.1XP_036017472.1  actin filament-associated protein 1-like 2 isoform X9

    Conserved Domains (4) summary
    PRK03918
    Location:496600
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13307
    Location:200300
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:327481
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
    cl17171
    Location:199
    PH-like; Pleckstrin homology-like domain
  9. XM_036161578.1XP_036017471.1  actin filament-associated protein 1-like 2 isoform X8

    Conserved Domains (4) summary
    PRK03918
    Location:553657
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd13306
    Location:50156
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:257357
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    NF033201
    Location:384538
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip