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AFAP1L2 actin filament associated protein 1 like 2 [ Homo sapiens (human) ]

Gene ID: 84632, updated on 1-Jun-2020

Summary

Official Symbol
AFAP1L2provided by HGNC
Official Full Name
actin filament associated protein 1 like 2provided by HGNC
Primary source
HGNC:HGNC:25901
See related
Ensembl:ENSG00000169129 MIM:612420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XB130; KIAA1914; CTB-1144G6.4
Expression
Broad expression in thyroid (RPKM 34.2), spleen (RPKM 23.9) and 15 other tissues See more
Orthologs

Genomic context

See AFAP1L2 in Genome Data Viewer
Location:
10q25.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (114280760..114404778, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116041248..116164515, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tudor domain containing 1 Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene uncharacterized LOC105378494 Neighboring gene RNA, 7SL, cytoplasmic 384, pseudogene Neighboring gene actin binding LIM protein 1 Neighboring gene peptidylprolyl isomerase A pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
actin filament-associated protein 1-like 2
Names
AFAP1-like protein 2
CTB-1144G6.6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001936.3NP_001001936.1  actin filament-associated protein 1-like 2 isoform 1

    See identical proteins and their annotated locations for NP_001001936.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
    Source sequence(s)
    AB067501, AC005383, AK123108, BC024314, BC033212, BC035713
    Consensus CDS
    CCDS31286.1
    UniProtKB/Swiss-Prot
    Q8N4X5
    Related
    ENSP00000303042.4, ENST00000304129.9
    Conserved Domains (4) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:171270
    PH; PH domain
    pfam06583
    Location:516666
    Neogenin_C; Neogenin C-terminus
  2. NM_001287824.1NP_001274753.1  actin filament-associated protein 1-like 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AB067501, AC005383, AK123108, AK291712, AK294969, AL133384, BC024314, BC035713
    UniProtKB/Swiss-Prot
    Q8N4X5
    UniProtKB/TrEMBL
    B7Z2Q0
    Conserved Domains (4) summary
    cd13306
    Location:218324
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:406506
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:224323
    PH; PH domain
    pfam06583
    Location:569719
    Neogenin_C; Neogenin C-terminus
  3. NM_001351064.1NP_001337993.1  actin filament-associated protein 1-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AL133384, BC024314, BM918355, DB362446
    Conserved Domains (4) summary
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:371471
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:699765
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:531659
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. NM_001351065.1NP_001337994.1  actin filament-associated protein 1-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA213501
    Conserved Domains (3) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:710776
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001351066.1NP_001337995.1  actin filament-associated protein 1-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA213501
    Conserved Domains (3) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:627693
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001351067.1NP_001337996.1  actin filament-associated protein 1-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, BM918355, HY263017
    Conserved Domains (4) summary
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:371471
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:699765
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:531659
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  7. NM_001351068.1NP_001337997.1  actin filament-associated protein 1-like 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, BE168197, BM918355
    Conserved Domains (3) summary
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:371471
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:700766
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001351069.1NP_001337998.1  actin filament-associated protein 1-like 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, AL702879, BC024314, BC033212, BC035713, HY263017
    Conserved Domains (4) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:681747
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:513641
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  9. NM_001351070.1NP_001337999.1  actin filament-associated protein 1-like 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, BE168197, BM918355, CN298045
    Conserved Domains (3) summary
    cd13306
    Location:109215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:626692
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001351071.1NP_001338000.1  actin filament-associated protein 1-like 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA122692, DA213501
    Conserved Domains (3) summary
    cd13306
    Location:137243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:654720
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001351072.1NP_001338001.1  actin filament-associated protein 1-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA122692, DA213501, HY263017
    Conserved Domains (3) summary
    cd13306
    Location:137243
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:325425
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:653719
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001351073.1NP_001338002.1  actin filament-associated protein 1-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, BE168197, BM918355, CN298045, HY263017
    Conserved Domains (3) summary
    cd13306
    Location:109215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:625691
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001351074.1NP_001338003.1  actin filament-associated protein 1-like 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, AL702879, BC024314, BC033212, BC035713, HY263017
    Conserved Domains (4) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:681747
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:513641
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  14. NM_001351075.1NP_001338004.1  actin filament-associated protein 1-like 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, AL702879, BC024314, BC033212, BC035713, BI053053, BM544228, DA164690, DA785568
    Conserved Domains (3) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:599665
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001351076.1NP_001338005.1  actin filament-associated protein 1-like 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, AL702879, BC024314, BC033212, BC035713, BI053053, BM544228, DA164690, DA785568
    Conserved Domains (3) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:599665
    SMC_N; RecF/RecN/SMC N terminal domain
  16. NM_001351077.1NP_001338006.1  actin filament-associated protein 1-like 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA213501, DB362446
    Conserved Domains (3) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:709775
    SMC_N; RecF/RecN/SMC N terminal domain
  17. NM_001351078.1NP_001338007.1  actin filament-associated protein 1-like 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA213501
    Conserved Domains (3) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:710776
    SMC_N; RecF/RecN/SMC N terminal domain
  18. NM_001351079.1NP_001338008.1  actin filament-associated protein 1-like 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, DA213501, DB362446
    Conserved Domains (4) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:709775
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:541669
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  19. NM_001351080.1NP_001338009.1  actin filament-associated protein 1-like 2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AB067501, AC005383, AK123108, AL133384, BC024314, BC033212, BC035713, BM544228, DA213501
    Conserved Domains (3) summary
    cd13306
    Location:193299
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:381481
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    cl25732
    Location:627693
    SMC_N; RecF/RecN/SMC N terminal domain
  20. NM_032550.3NP_115939.1  actin filament-associated protein 1-like 2 isoform 2

    See identical proteins and their annotated locations for NP_115939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes isoform 2, which is shorter than isoform 3.
    Source sequence(s)
    AB067501, AC005383, AL133384, BC024314
    Consensus CDS
    CCDS31287.1
    UniProtKB/Swiss-Prot
    Q8N4X5
    Related
    ENSP00000358276.3, ENST00000369271.7
    Conserved Domains (4) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:171270
    PH; PH domain
    pfam06583
    Location:516666
    Neogenin_C; Neogenin C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    114280760..114404778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270233.4XP_005270290.1  actin filament-associated protein 1-like 2 isoform X5

    Conserved Domains (4) summary
    cd13306
    Location:183289
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:371471
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:189288
    PH; PH domain
    pfam06583
    Location:534684
    Neogenin_C; Neogenin C-terminus
  2. XM_017016795.1XP_016872284.1  actin filament-associated protein 1-like 2 isoform X1

  3. XM_005270241.4XP_005270298.1  actin filament-associated protein 1-like 2 isoform X11

    Conserved Domains (4) summary
    cd13306
    Location:109215
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:297397
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:115214
    PH; PH domain
    pfam06583
    Location:460610
    Neogenin_C; Neogenin C-terminus
  4. XM_017016814.1XP_016872303.1  actin filament-associated protein 1-like 2 isoform X9

  5. XM_005270237.5XP_005270294.1  actin filament-associated protein 1-like 2 isoform X6

    Conserved Domains (4) summary
    cd13306
    Location:165271
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:353453
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:171270
    PH; PH domain
    pfam06583
    Location:516666
    Neogenin_C; Neogenin C-terminus
  6. XM_017016818.1XP_016872307.1  actin filament-associated protein 1-like 2 isoform X10

  7. XM_017016797.1XP_016872286.1  actin filament-associated protein 1-like 2 isoform X3

  8. XM_017016796.1XP_016872285.1  actin filament-associated protein 1-like 2 isoform X2

  9. XM_005270242.4XP_005270299.1  actin filament-associated protein 1-like 2 isoform X12

    Conserved Domains (4) summary
    cd13306
    Location:199
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:181281
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:198
    PH; PH domain
    pfam06583
    Location:344494
    Neogenin_C; Neogenin C-terminus
  10. XM_017016829.1XP_016872318.1  actin filament-associated protein 1-like 2 isoform X12

    Conserved Domains (4) summary
    cd13306
    Location:199
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:181281
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:198
    PH; PH domain
    pfam06583
    Location:344494
    Neogenin_C; Neogenin C-terminus
  11. XM_017016832.1XP_016872321.1  actin filament-associated protein 1-like 2 isoform X15

  12. XM_017016798.2XP_016872287.1  actin filament-associated protein 1-like 2 isoform X4

  13. XM_017016804.2XP_016872293.1  actin filament-associated protein 1-like 2 isoform X7

  14. XM_017016810.1XP_016872299.1  actin filament-associated protein 1-like 2 isoform X8

  15. XM_017016830.1XP_016872319.1  actin filament-associated protein 1-like 2 isoform X13

  16. XM_017016831.1XP_016872320.1  actin filament-associated protein 1-like 2 isoform X14

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