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Ermp1 endoplasmic reticulum metallopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 226090, updated on 18-Apr-2024

Summary

Official Symbol
Ermp1provided by MGI
Official Full Name
endoplasmic reticulum metallopeptidase 1provided by MGI
Primary source
MGI:MGI:106250
See related
Ensembl:ENSMUSG00000046324 AllianceGenome:MGI:106250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxna; D19Wsu12e; mKIAA1815; b2b2633Clo; D19Ertd410e
Summary
Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in cellular response to oxidative stress; ovarian follicle development; and proteolysis. Predicted to act upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and sensory organ. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 65.2), genital fat pad adult (RPKM 14.2) and 22 other tissues See more
Orthologs
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Genomic context

Location:
19 C1; 19 24.17 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29587276..29625815, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29609876..29648415, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930007I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E8745 Neighboring gene RAB6A GEF complex partner 1 Neighboring gene STARR-seq mESC enhancer starr_45891 Neighboring gene predicted gene, 36126 Neighboring gene STARR-seq mESC enhancer starr_45893 Neighboring gene melan-A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28180

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endoplasmic reticulum metallopeptidase 1
Names
aminopeptidase Fxna
felix-ina

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081213.2NP_001074682.1  endoplasmic reticulum metallopeptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_001074682.1

    Status: VALIDATED

    Source sequence(s)
    AC114578
    Consensus CDS
    CCDS37952.1
    UniProtKB/Swiss-Prot
    B2RXD6, Q3UVK0, Q6ZPH9, Q8BIW0, Q8BYX7
    Related
    ENSMUSP00000124881.2, ENSMUST00000159692.8
    Conserved Domains (1) summary
    cd03875
    Location:99406
    M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
  2. NM_001362131.1NP_001349060.1  endoplasmic reticulum metallopeptidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114578
    Conserved Domains (1) summary
    cd03875
    Location:99406
    M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29587276..29625815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)