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Xpc xeroderma pigmentosum, complementation group C [ Mus musculus (house mouse) ]

Gene ID: 22591, updated on 2-Oct-2018

Summary

Official Symbol
Xpcprovided by MGI
Official Full Name
xeroderma pigmentosum, complementation group Cprovided by MGI
Primary source
MGI:MGI:103557
See related
Ensembl:ENSMUSG00000030094 Vega:OTTMUSG00000024133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), kidney adult (RPKM 5.1) and 28 other tissues See more
Orthologs

Genomic context

See Xpc in Genome Data Viewer
Location:
6; 6 D1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (91489305..91515888, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (91439299..91465882, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 Neighboring gene transmembrane protein 43 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
intra-S DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair, DNA damage recognition ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
response to UV-B IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
XPC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
XPC complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair complex ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair protein complementing XP-C cells homolog
Names
p125
xeroderma pigmentosum group C-complementing protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009531.2NP_033557.2  DNA repair protein complementing XP-C cells homolog

    See identical proteins and their annotated locations for NP_033557.2

    Status: VALIDATED

    Source sequence(s)
    AK028595, BY238377, DV645509
    Consensus CDS
    CCDS39569.1
    UniProtKB/Swiss-Prot
    P51612
    Related
    ENSMUSP00000032182.3, OTTMUSP00000028684, ENSMUST00000032182.4, OTTMUST00000059041
    Conserved Domains (6) summary
    smart01032
    Location:744818
    BHD_3; Rad4 beta-hairpin domain 3
    smart01030
    Location:623674
    BHD_1; Rad4 beta-hairpin domain 1
    smart01031
    Location:677736
    BHD_2; Rad4 beta-hairpin domain 2
    PHA03249
    Location:345455
    PHA03249; DNA packaging tegument protein UL25; Provisional
    TIGR00605
    Location:143859
    rad4; DNA repair protein rad4
    pfam03835
    Location:501619
    Rad4; Rad4 transglutaminase-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    91489305..91515888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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