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Xpc xeroderma pigmentosum, complementation group C [ Mus musculus (house mouse) ]

Gene ID: 22591, updated on 5-Mar-2024

Summary

Official Symbol
Xpcprovided by MGI
Official Full Name
xeroderma pigmentosum, complementation group Cprovided by MGI
Primary source
MGI:MGI:103557
See related
Ensembl:ENSMUSG00000030094 AllianceGenome:MGI:103557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and damaged DNA binding activity. Involved in UV-damage excision repair. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling; pyrimidine dimer repair by nucleotide-excision repair; and response to UV. Located in nucleus and site of DNA damage. Used to study lung cancer and xeroderma pigmentosum group C. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), kidney adult (RPKM 5.1) and 28 other tissues See more
Orthologs
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Genomic context

See Xpc in Genome Data Viewer
Location:
6 D1; 6 40.55 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91466287..91492870, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91489305..91515888, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16640 Neighboring gene STARR-seq mESC enhancer starr_16641 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 Neighboring gene transmembrane protein 43 Neighboring gene predicted gene, 52912 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:91456115-91456352 Neighboring gene STARR-positive B cell enhancer ABC_E9671 Neighboring gene STARR-seq mESC enhancer starr_16643 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:91629122-91629420 Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA damage sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in UV-damage excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nucleotide-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pyrimidine dimer repair by nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of XPC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of XPC complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-excision repair complex ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-excision repair factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA repair protein complementing XP-C cells homolog
Names
p125
xeroderma pigmentosum group C-complementing protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009531.2NP_033557.2  DNA repair protein complementing XP-C cells homolog

    See identical proteins and their annotated locations for NP_033557.2

    Status: VALIDATED

    Source sequence(s)
    AK028595, BY238377, DV645509
    Consensus CDS
    CCDS39569.1
    UniProtKB/Swiss-Prot
    P51612, P54732, Q3TKI2, Q920M1, Q9DBW7
    UniProtKB/TrEMBL
    Q7TSZ1
    Related
    ENSMUSP00000032182.4, ENSMUST00000032182.5
    Conserved Domains (6) summary
    smart01032
    Location:744818
    BHD_3; Rad4 beta-hairpin domain 3
    smart01030
    Location:623674
    BHD_1; Rad4 beta-hairpin domain 1
    smart01031
    Location:677736
    BHD_2; Rad4 beta-hairpin domain 2
    PHA03249
    Location:345455
    PHA03249; DNA packaging tegument protein UL25; Provisional
    TIGR00605
    Location:143859
    rad4; DNA repair protein rad4
    pfam03835
    Location:501619
    Rad4; Rad4 transglutaminase-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    91466287..91492870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)