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Kmt5b lysine methyltransferase 5B [ Mus musculus (house mouse) ]

Gene ID: 225888, updated on 12-May-2024

Summary

Official Symbol
Kmt5bprovided by MGI
Official Full Name
lysine methyltransferase 5Bprovided by MGI
Primary source
MGI:MGI:2444557
See related
Ensembl:ENSMUSG00000045098 AllianceGenome:MGI:2444557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suv420h1; Suv4-20h1; C630029K18Rik
Summary
Enables S-adenosyl-L-methionine binding activity and histone methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone methylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 51. Orthologous to human KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.3), CNS E14 (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Kmt5b in Genome Data Viewer
Location:
19 A; 19 3.5 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3816436..3868303)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3767362..3818303)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810055G02 gene Neighboring gene STARR-positive B cell enhancer ABC_E5671 Neighboring gene predicted gene, 36787 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45327 Neighboring gene STARR-seq mESC enhancer starr_45328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:3767926-3768113 Neighboring gene STARR-positive B cell enhancer ABC_E5672 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_45331 Neighboring gene microRNA 12192

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC18702

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H4K20 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K20me methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase KMT5B
Names
[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
[histone H4]-lysine20 N-methyltransferase KMT5B
histone-lysine N-methyltransferase SUV420H1
lysine-specific methyltransferase 5B
su(var)4-20 homolog 1
suppressor of variegation 4-20 homolog 1
NP_001161356.1
NP_001161357.1
NP_001161358.1
NP_001161359.1
NP_001161360.1
NP_001161361.1
NP_001366607.1
NP_001366608.1
NP_001366609.1
NP_659120.3
XP_006531790.1
XP_006531791.1
XP_011246926.1
XP_017173633.1
XP_030106737.1
XP_036017420.1
XP_036017421.1
XP_036017422.1
XP_036017423.1
XP_036017424.1
XP_036017425.1
XP_036017426.1
XP_036017427.1
XP_036017428.1
XP_036017429.1
XP_036017430.1
XP_036017431.1
XP_036017432.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167884.1NP_001161356.1  histone-lysine N-methyltransferase KMT5B isoform d

    See identical proteins and their annotated locations for NP_001161356.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AK087267
    Consensus CDS
    CCDS50345.1
    UniProtKB/Swiss-Prot
    Q3U8K7
    Related
    ENSMUSP00000109601.3, ENSMUST00000113968.9
    Conserved Domains (1) summary
    smart00317
    Location:204315
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  2. NM_001167885.1NP_001161357.1  histone-lysine N-methyltransferase KMT5B isoform a

    See identical proteins and their annotated locations for NP_001161357.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AK152179, AY555192
    Consensus CDS
    CCDS50343.1
    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Related
    ENSMUSP00000109606.2, ENSMUST00000113973.8
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  3. NM_001167886.1NP_001161358.1  histone-lysine N-methyltransferase KMT5B isoform b

    See identical proteins and their annotated locations for NP_001161358.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AY555192
    Consensus CDS
    CCDS29399.1
    UniProtKB/Swiss-Prot
    Q3U8K7
    Related
    ENSMUSP00000109610.3, ENSMUST00000113977.9
    Conserved Domains (1) summary
    cd19184
    Location:170313
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  4. NM_001167887.1NP_001161359.1  histone-lysine N-methyltransferase KMT5B isoform a

    See identical proteins and their annotated locations for NP_001161359.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AY555192
    Consensus CDS
    CCDS50343.1
    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Related
    ENSMUSP00000109605.3, ENSMUST00000113972.9
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  5. NM_001167888.1NP_001161360.1  histone-lysine N-methyltransferase KMT5B isoform d

    See identical proteins and their annotated locations for NP_001161360.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AK087267, AK152179
    Consensus CDS
    CCDS50345.1
    UniProtKB/Swiss-Prot
    Q3U8K7
    Related
    ENSMUSP00000158061.2, ENSMUST00000237440.2
    Conserved Domains (1) summary
    smart00317
    Location:204315
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  6. NM_001167889.2NP_001161361.1  histone-lysine N-methyltransferase KMT5B isoform c

    See identical proteins and their annotated locations for NP_001161361.1

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK082660, AK083227
    Consensus CDS
    CCDS50344.1
    UniProtKB/TrEMBL
    H3BLE5
    Related
    ENSMUSP00000060162.7, ENSMUST00000052699.13
    Conserved Domains (1) summary
    smart00317
    Location:204315
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  7. NM_001379678.1NP_001366607.1  histone-lysine N-methyltransferase KMT5B isoform a

    Status: VALIDATED

    Source sequence(s)
    AC132452
    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  8. NM_001379679.1NP_001366608.1  histone-lysine N-methyltransferase KMT5B isoform b

    Status: VALIDATED

    Source sequence(s)
    AC132452
    Related
    ENSMUSP00000135563.2, ENSMUST00000176262.8
    Conserved Domains (1) summary
    cd19184
    Location:170313
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  9. NM_001379680.1NP_001366609.1  histone-lysine N-methyltransferase KMT5B isoform e

    Status: VALIDATED

    Source sequence(s)
    AC132452
    Conserved Domains (1) summary
    cl40432
    Location:193276
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  10. NM_144871.4NP_659120.3  histone-lysine N-methyltransferase KMT5B isoform b

    See identical proteins and their annotated locations for NP_659120.3

    Status: VALIDATED

    Source sequence(s)
    AC132452, AK083227, AY555192
    Consensus CDS
    CCDS29399.1
    UniProtKB/Swiss-Prot
    Q3U8K7
    Related
    ENSMUSP00000109607.5, ENSMUST00000113974.11
    Conserved Domains (1) summary
    cd19184
    Location:170313
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3816436..3868303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531727.5XP_006531790.1  histone-lysine N-methyltransferase KMT5B isoform X1

    See identical proteins and their annotated locations for XP_006531790.1

    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  2. XM_036161533.1XP_036017426.1  histone-lysine N-methyltransferase KMT5B isoform X7

  3. XM_017318144.3XP_017173633.1  histone-lysine N-methyltransferase KMT5B isoform X3

    Conserved Domains (1) summary
    cd19184
    Location:151294
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  4. XM_036161527.1XP_036017420.1  histone-lysine N-methyltransferase KMT5B isoform X1

    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  5. XM_036161528.1XP_036017421.1  histone-lysine N-methyltransferase KMT5B isoform X1

    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  6. XM_036161534.1XP_036017427.1  histone-lysine N-methyltransferase KMT5B isoform X7

  7. XM_036161539.1XP_036017432.1  histone-lysine N-methyltransferase KMT5B isoform X10

    Conserved Domains (1) summary
    cl40432
    Location:193275
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  8. XM_036161538.1XP_036017431.1  histone-lysine N-methyltransferase KMT5B isoform X9

    Conserved Domains (1) summary
    cl40432
    Location:193326
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  9. XM_036161531.1XP_036017424.1  histone-lysine N-methyltransferase KMT5B isoform X6

    Conserved Domains (1) summary
    cd19184
    Location:170313
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  10. XM_036161530.1XP_036017423.1  histone-lysine N-methyltransferase KMT5B isoform X5

    Conserved Domains (1) summary
    cd19184
    Location:128271
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  11. XM_011248624.3XP_011246926.1  histone-lysine N-methyltransferase KMT5B isoform X2

    See identical proteins and their annotated locations for XP_011246926.1

    UniProtKB/Swiss-Prot
    Q3U8K7
    Conserved Domains (1) summary
    cd19184
    Location:170313
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  12. XM_036161529.1XP_036017422.1  histone-lysine N-methyltransferase KMT5B isoform X4

    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  13. XM_036161535.1XP_036017428.1  histone-lysine N-methyltransferase KMT5B isoform X7

  14. XM_036161532.1XP_036017425.1  histone-lysine N-methyltransferase KMT5B isoform X7

  15. XM_036161537.1XP_036017430.1  histone-lysine N-methyltransferase KMT5B isoform X7

  16. XM_030250877.2XP_030106737.1  histone-lysine N-methyltransferase KMT5B isoform X8

  17. XM_006531728.5XP_006531791.1  histone-lysine N-methyltransferase KMT5B isoform X1

    See identical proteins and their annotated locations for XP_006531791.1

    UniProtKB/Swiss-Prot
    Q3U8K7, Q3UTP6, Q6DI74, Q6Q784, Q8BU67, Q8BUN0, Q8BUT7, Q8BW73, Q8BZ24, Q91X81
    Conserved Domains (1) summary
    cd19184
    Location:193336
    SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
  18. XM_036161536.1XP_036017429.1  histone-lysine N-methyltransferase KMT5B isoform X7