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FGF10 fibroblast growth factor 10 [ Homo sapiens (human) ]

Gene ID: 2255, updated on 9-Oct-2022

Summary

Official Symbol
FGF10provided by HGNC
Official Full Name
fibroblast growth factor 10provided by HGNC
Primary source
HGNC:HGNC:3666
See related
Ensembl:ENSG00000070193 MIM:602115; AllianceGenome:HGNC:3666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See FGF10 in Genome Data Viewer
Location:
5p12
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (44300247..44389420, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (44553832..44642982, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (44300349..44389522, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 12 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene RNA, U6 small nuclear 381, pseudogene Neighboring gene VISTA enhancer hs516 Neighboring gene FGF10 intronic enhancer Neighboring gene FGF10 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2224 Neighboring gene RNA, 7SL, cytoplasmic 383, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital absence of salivary gland
MedGen: C0158667 OMIM: 180920 GeneReviews: Not available
Compare labs
Levy-Hollister syndrome
MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2022-02-23)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-23)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 10 (FGF10) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type 2 fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Harderian gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in branch elongation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bronchiole morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bud outgrowth involved in lung branching IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell proliferation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in female genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway involved in mammary gland specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in lacrimal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in limb development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lung epithelium development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lung proximal/distal axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in lung saccule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell differentiation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal-epithelial cell signaling involved in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in organ induction IEA
Inferred from Electronic Annotation
more info
 
involved_in otic vesicle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation involved in wound healing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of hair follicle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of keratinocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lymphocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of urothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of urothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of white fat cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
involved_in radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secretion by lung epithelial cell involved in lung growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in secretion by lung epithelial cell involved in lung growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in semicircular canal fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in submandibular salivary gland formation IEA
Inferred from Electronic Annotation
more info
 
involved_in tear secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thymus development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in urothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in white fat cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 10
Names
FGF-10
keratinocyte growth factor 2
produced by fibroblasts of urinary bladder lamina propria

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011446.1 RefSeqGene

    Range
    5001..88688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004465.2NP_004456.1  fibroblast growth factor 10 precursor

    See identical proteins and their annotated locations for NP_004456.1

    Status: REVIEWED

    Source sequence(s)
    AB002097, AC093537, BX955123, DA795795, DR003252
    Consensus CDS
    CCDS3950.1
    UniProtKB/Swiss-Prot
    O15520, Q96P59
    UniProtKB/TrEMBL
    A0A7U3JW18
    Related
    ENSP00000264664.4, ENST00000264664.5
    Conserved Domains (1) summary
    pfam00167
    Location:78202
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    44300247..44389420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248264.5XP_005248321.1  fibroblast growth factor 10 isoform X1

    See identical proteins and their annotated locations for XP_005248321.1

    UniProtKB/Swiss-Prot
    O15520, Q96P59
    UniProtKB/TrEMBL
    A0A7U3JW18
    Conserved Domains (1) summary
    pfam00167
    Location:78202
    FGF; Fibroblast growth factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    44553832..44642982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)