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FGF10 fibroblast growth factor 10 [ Homo sapiens (human) ]

Gene ID: 2255, updated on 13-Mar-2020

Summary

Official Symbol
FGF10provided by HGNC
Official Full Name
fibroblast growth factor 10provided by HGNC
Primary source
HGNC:HGNC:3666
See related
Ensembl:ENSG00000070193 MIM:602115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues See more
Orthologs

Genomic context

See FGF10 in Genome Data Viewer
Location:
5p12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (44300247..44389706, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (44305004..44389808, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 12 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene RNA, U6 small nuclear 381, pseudogene Neighboring gene VISTA enhancer hs516 Neighboring gene FGF10 intronic enhancer Neighboring gene FGF10 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2224 Neighboring gene RNA, 7SL, cytoplasmic 383, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital absence of salivary gland
MedGen: C0158667 OMIM: 180920 GeneReviews: Not available
Compare labs
Levy-Hollister syndrome
MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2020-02-26)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2020-02-26)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 10 (FGF10) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 2 fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
Harderian gland development IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
branch elongation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
bronchiole morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
bud outgrowth involved in lung branching IDA
Inferred from Direct Assay
more info
PubMed 
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
embryonic digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
female genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway involved in mammary gland specification IDA
Inferred from Direct Assay
more info
PubMed 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
lacrimal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb bud formation IEA
Inferred from Electronic Annotation
more info
 
lung epithelium development IDA
Inferred from Direct Assay
more info
PubMed 
lung proximal/distal axis specification IEA
Inferred from Electronic Annotation
more info
 
lung saccule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mammary gland bud formation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell differentiation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal-epithelial cell signaling involved in lung development IEA
Inferred from Electronic Annotation
more info
 
mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
muscle cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
otic vesicle formation IEA
Inferred from Electronic Annotation
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation involved in wound healing NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hair follicle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lymphocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of urothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of white fat cell proliferation IEA
Inferred from Electronic Annotation
more info
 
prostatic bud formation IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretion by lung epithelial cell involved in lung growth IDA
Inferred from Direct Assay
more info
PubMed 
semicircular canal fusion IEA
Inferred from Electronic Annotation
more info
 
smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
submandibular salivary gland formation IEA
Inferred from Electronic Annotation
more info
 
tear secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IDA
Inferred from Direct Assay
more info
PubMed 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
urothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 10
Names
FGF-10
keratinocyte growth factor 2
produced by fibroblasts of urinary bladder lamina propria

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011446.1 RefSeqGene

    Range
    5001..88688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004465.2NP_004456.1  fibroblast growth factor 10 precursor

    See identical proteins and their annotated locations for NP_004456.1

    Status: REVIEWED

    Source sequence(s)
    AB002097, AC093537, BX955123, DA795795, DR003252
    Consensus CDS
    CCDS3950.1
    UniProtKB/Swiss-Prot
    O15520
    Related
    ENSP00000264664.4, ENST00000264664.5
    Conserved Domains (1) summary
    smart00442
    Location:76204
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    44300247..44389706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248264.4XP_005248321.1  fibroblast growth factor 10 isoform X1

    See identical proteins and their annotated locations for XP_005248321.1

    UniProtKB/Swiss-Prot
    O15520
    Conserved Domains (1) summary
    smart00442
    Location:76204
    FGF; Acidic and basic fibroblast growth factor family
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