FGF10 fibroblast growth factor 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGF10provided by HGNC
Official Full Name: fibroblast growth factor 10provided by HGNC
Primary source: HGNC:HGNC:3666
See related: Ensembl:ENSG00000070193 MIM:602115
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Expression: Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	5	NC_000005.10 (44300247..44389706, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (44305004..44389808, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytokine fibroblast growth factor 10 (FGF10) polymorphisms are associated with risk of myopia in young children.
Title: Cytokine fibroblast growth factor 10 (FGF10) polymorphisms are associated with risk of myopia in young children.
miR-145 promotes the EMT during the development of peritoneal fibrosis by suppressing FGF10 activity
Title: MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10.
Genetic polymorphisms in FGF3, FGF10, and FGF13 genes were associated with temporomandibular disorders in a population with dentofacial deformities
Title: Polymorphisms in FGF3, FGF10, and FGF13 May Contribute to the Presence of Temporomandibular Disorders in Patients Who Required Orthognathic Surgery.
Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway
Title: Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway.
We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene.
Title: New pathogenic variant in the FGF10 gene in the agenesis of lacrimal and salivary gland syndrome: Ophthalmological and genetic study.
We have revealed significant association of FGFR2 and MAP3K1 polymorphisms with breast cancer.
Title: Association of single nucleotide polymorphisms in FGF-RAS/MAP signalling cascade with breast cancer susceptibility.
These results indicated that FGF-2, but not FGF-10, may be supplemented during stem cell expansion to prime cells for successful chondrogenesis and osteogenesis.
Title: Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
The present data indicate that non-natural FGFR2 ligands, such as FGF10 and FGF19, are important factors in the pathophysiology of Aspert syndrome.
Title: Cell Type-Dependent Nonspecific Fibroblast Growth Factor Signaling in Apert Syndrome.
data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis
Title: Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development
Title: Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital absence of salivary gland MedGen: C0158667 OMIM: 180920 GeneReviews: Not available	Compare labs
Levy-Hollister syndrome MedGen: C0265269 OMIM: 149730 GeneReviews: Not available	Compare labs
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. GeneReviews: Not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated (2020-02-26) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated (2020-02-26) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 10 (FGF10) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481074

SHGC-82302 (e-PCR)
- UniSTS:104243

NoName (e-PCR)
- UniSTS:483140

Fgf10 (e-PCR), detects polymorphism
- UniSTS:536432

G16001 (e-PCR)
- UniSTS:11918

SHGC-100998 (e-PCR)
- UniSTS:183961

SHGC-110572 (e-PCR)
- UniSTS:167910

Homology

Homologs of the FGF10 gene: The FGF10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 294 organisms have orthologs with human gene FGF10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth factor activity	IDA Inferred from Direct Assay more info	PubMed
heparin binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
type 2 fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
Harderian gland development	IEA Inferred from Electronic Annotation more info
MAPK cascade	TAS Traceable Author Statement more info
actin cytoskeleton reorganization	IDA Inferred from Direct Assay more info	PubMed
activation of MAPK activity	IDA Inferred from Direct Assay more info	PubMed
angiogenesis	IEA Inferred from Electronic Annotation more info
animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
branch elongation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
bronchiole morphogenesis	IEA Inferred from Electronic Annotation more info
bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
bud outgrowth involved in lung branching	IDA Inferred from Direct Assay more info	PubMed
cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
embryonic camera-type eye development	IEA Inferred from Electronic Annotation more info
embryonic digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
embryonic genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
embryonic pattern specification	IEA Inferred from Electronic Annotation more info
epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
epithelial cell proliferation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
female genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fibroblast growth factor receptor signaling pathway	TAS Traceable Author Statement more info
fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IDA Inferred from Direct Assay more info	PubMed
hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
lacrimal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
limb bud formation	IEA Inferred from Electronic Annotation more info
limb development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
lung epithelium development	IDA Inferred from Direct Assay more info	PubMed
lung proximal/distal axis specification	IEA Inferred from Electronic Annotation more info
lung saccule development	IMP Inferred from Mutant Phenotype more info	PubMed
male genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
mammary gland bud formation	IEA Inferred from Electronic Annotation more info
mesenchymal cell differentiation involved in lung development	IEA Inferred from Electronic Annotation more info
mesenchymal-epithelial cell signaling involved in lung development	IEA Inferred from Electronic Annotation more info
mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
metanephros development	IEP Inferred from Expression Pattern more info	PubMed
metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
muscle cell fate commitment	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
organ induction	IEA Inferred from Electronic Annotation more info
otic vesicle formation	IEA Inferred from Electronic Annotation more info
pancreas development	IEA Inferred from Electronic Annotation more info
pituitary gland development	IEA Inferred from Electronic Annotation more info
positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ATPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of epithelial cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of epithelial cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial cell proliferation involved in wound healing	NAS Non-traceable Author Statement more info	PubMed
positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of hair follicle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of keratinocyte migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of keratinocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase B signaling	TAS Traceable Author Statement more info
positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of urothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of white fat cell proliferation	IEA Inferred from Electronic Annotation more info
prostatic bud formation	IEA Inferred from Electronic Annotation more info
protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IEA Inferred from Electronic Annotation more info
regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of saliva secretion	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
response to estradiol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
secretion by lung epithelial cell involved in lung growth	IBA Inferred from Biological aspect of Ancestor more info	PubMed
secretion by lung epithelial cell involved in lung growth	IDA Inferred from Direct Assay more info	PubMed
semicircular canal fusion	IEA Inferred from Electronic Annotation more info
smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
spleen development	IEA Inferred from Electronic Annotation more info
submandibular salivary gland formation	IEA Inferred from Electronic Annotation more info
tear secretion	IMP Inferred from Mutant Phenotype more info	PubMed
thymus development	IDA Inferred from Direct Assay more info	PubMed
thyroid gland development	IEA Inferred from Electronic Annotation more info
tissue regeneration	IEA Inferred from Electronic Annotation more info
type II pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
urothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
white fat cell differentiation	IEA Inferred from Electronic Annotation more info
wound healing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
cell surface	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 10

Names: FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.