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Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 225028, updated on 2-Nov-2024

Summary

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Official Symbol
Map4k3provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3provided by MGI
Primary source
MGI:MGI:2154405
See related
Ensembl:ENSMUSG00000024242 AllianceGenome:MGI:2154405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glk; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; 4833416M01Rik; 4833416M07Rik; 9530052P13Rik
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 16.8), limb E14.5 (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Map4k3 in Genome Data Viewer
Location:
17 E3; 17 50.97 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80887942..81039118, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80580513..80728806, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2500 Neighboring gene STARR-positive B cell enhancer ABC_E8925 Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene STARR-seq mESC enhancer starr_43318 Neighboring gene STARR-positive B cell enhancer ABC_E5633 Neighboring gene STARR-positive B cell enhancer ABC_E10973 Neighboring gene STARR-positive B cell enhancer ABC_E9172 Neighboring gene cyclin dependent kinase like 4 Neighboring gene STARR-positive B cell enhancer ABC_E4229 Neighboring gene STARR-positive B cell enhancer ABC_E616 Neighboring gene STARR-seq mESC enhancer starr_43322 Neighboring gene STARR-seq mESC enhancer starr_43326 Neighboring gene STARR-seq mESC enhancer starr_43329 Neighboring gene predicted gene 9959 Neighboring gene STARR-positive B cell enhancer mm9_chr17:81171844-81172145 Neighboring gene STARR-seq mESC enhancer starr_43332 Neighboring gene STARR-seq mESC enhancer starr_43333 Neighboring gene STARR-seq mESC enhancer starr_43334 Neighboring gene STARR-seq mESC enhancer starr_43335 Neighboring gene predicted gene, 33538 Neighboring gene predicted gene, 33596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation. Chi JN, et al. Theranostics, 2022. PMID 35966593, Free PMC Article
  2. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Chuang HC, et al. Nat Immunol, 2011 Oct 9. PMID 21983831
  3. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Chuang HC, et al. Sci Adv, 2018 Sep. PMID 30214937, Free PMC Article
  4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation.
    Title: MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.
  2. GLK induces IL-17A transcription by activating AhR and ROR-gammat.GLK controls IL-17A production and autoimmune responses through AhR.
    Title: GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 3
Names
MAPK/ERK kinase kinase kinase 3
MEK kinase kinase 3
germinal center kinase-related protein kinase
NP_001277274.1
NP_001347207.1
XP_006524255.1
XP_006524259.1
XP_006524260.1
XP_036016462.1
XP_036016463.1
XP_036016464.1
XP_036016465.1
XP_036016466.1
XP_036016467.1
XP_036016468.1
XP_036016469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290345.1 → NP_001277274.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_001277274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA289270, AI430883, AK014711, AK079249, BQ442103, CD353921, CF167620, CK618209, CO433380
    Consensus CDS
    CCDS70847.1
    UniProtKB/Swiss-Prot
    E9PWI4, Q99JP0, Q9CUS8
    UniProtKB/TrEMBL
    E9QNE9
    Related
    ENSMUSP00000025089.8, ENSMUST00000025089.9
    Conserved Domains (2) summary
    smart00036
    Location:561 → 874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  2. NM_001360278.1 → NP_001347207.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC131712, AC169501
    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:551 → 864
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80887942..81039118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160575.1 → XP_036016468.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:522 → 865
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  2. XM_006524197.4 → XP_006524260.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

    UniProtKB/TrEMBL
    A0A3Q4EGQ9, E9QNE9
    Related
    ENSMUSP00000157308.2, ENSMUST00000234133.2
    Conserved Domains (2) summary
    smart00036
    Location:540 → 853
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  3. XM_036160574.1 → XP_036016467.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:540 → 883
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  4. XM_036160572.1 → XP_036016465.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:551 → 894
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  5. XM_006524196.4 → XP_006524259.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:543 → 856
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  6. XM_036160573.1 → XP_036016466.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:543 → 886
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  7. XM_036160570.1 → XP_036016463.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:561 → 904
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  8. XM_036160571.1 → XP_036016464.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:554 → 897
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  9. XM_006524192.4 → XP_006524255.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:572 → 885
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  10. XM_036160569.1 → XP_036016462.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:572 → 915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15 → 273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  11. XM_036160576.1 → XP_036016469.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:483 → 826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 184
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081357.1: Suppressed sequence

    Description
    NM_001081357.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JP0.4 GenPept UniProtKB/Swiss-Prot:Q99JP0

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