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Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 225028, updated on 8-Feb-2024

Summary

Official Symbol
Map4k3provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3provided by MGI
Primary source
MGI:MGI:2154405
See related
Ensembl:ENSMUSG00000024242 AllianceGenome:MGI:2154405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glk; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; 4833416M01Rik; 4833416M07Rik; 9530052P13Rik
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to act upstream of or within phosphorylation. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 16.8), limb E14.5 (RPKM 14.8) and 28 other tissues See more
Orthologs
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Genomic context

See Map4k3 in Genome Data Viewer
Location:
17 E3; 17 50.97 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80887942..81039118, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80580513..80728806, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2500 Neighboring gene STARR-positive B cell enhancer ABC_E8925 Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene STARR-seq mESC enhancer starr_43318 Neighboring gene STARR-positive B cell enhancer ABC_E5633 Neighboring gene STARR-positive B cell enhancer ABC_E10973 Neighboring gene STARR-positive B cell enhancer ABC_E9172 Neighboring gene cyclin dependent kinase like 4 Neighboring gene STARR-positive B cell enhancer ABC_E4229 Neighboring gene STARR-positive B cell enhancer ABC_E616 Neighboring gene STARR-seq mESC enhancer starr_43322 Neighboring gene STARR-seq mESC enhancer starr_43326 Neighboring gene STARR-seq mESC enhancer starr_43329 Neighboring gene predicted gene 9959 Neighboring gene STARR-positive B cell enhancer mm9_chr17:81171844-81172145 Neighboring gene STARR-seq mESC enhancer starr_43332 Neighboring gene STARR-seq mESC enhancer starr_43333 Neighboring gene STARR-seq mESC enhancer starr_43334 Neighboring gene STARR-seq mESC enhancer starr_43335 Neighboring gene predicted gene, 33538 Neighboring gene predicted gene, 33596

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 3
Names
MAPK/ERK kinase kinase kinase 3
MEK kinase kinase 3
germinal center kinase-related protein kinase
NP_001277274.1
NP_001347207.1
XP_006524255.1
XP_006524259.1
XP_006524260.1
XP_036016462.1
XP_036016463.1
XP_036016464.1
XP_036016465.1
XP_036016466.1
XP_036016467.1
XP_036016468.1
XP_036016469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290345.1NP_001277274.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_001277274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA289270, AI430883, AK014711, AK079249, BQ442103, CD353921, CF167620, CK618209, CO433380
    Consensus CDS
    CCDS70847.1
    UniProtKB/Swiss-Prot
    E9PWI4, Q99JP0, Q9CUS8
    UniProtKB/TrEMBL
    E9QNE9
    Related
    ENSMUSP00000025089.8, ENSMUST00000025089.9
    Conserved Domains (2) summary
    smart00036
    Location:561874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. NM_001360278.1NP_001347207.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC131712, AC169501
    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:551864
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80887942..81039118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160575.1XP_036016468.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:522865
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_006524197.4XP_006524260.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

    UniProtKB/TrEMBL
    A0A3Q4EGQ9, E9QNE9
    Related
    ENSMUSP00000157308.2, ENSMUST00000234133.2
    Conserved Domains (2) summary
    smart00036
    Location:540853
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  3. XM_036160574.1XP_036016467.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:540883
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  4. XM_036160572.1XP_036016465.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:551894
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  5. XM_006524196.4XP_006524259.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:543856
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  6. XM_036160573.1XP_036016466.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:543886
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  7. XM_036160570.1XP_036016463.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:561904
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  8. XM_036160571.1XP_036016464.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:554897
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  9. XM_006524192.4XP_006524255.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:572885
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  10. XM_036160569.1XP_036016462.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:572915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  11. XM_036160576.1XP_036016469.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

    UniProtKB/TrEMBL
    E9QNE9
    Conserved Domains (2) summary
    smart00036
    Location:483826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1184
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081357.1: Suppressed sequence

    Description
    NM_001081357.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.