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MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 [ Homo sapiens (human) ]

Gene ID: 8491, updated on 12-Oct-2019

Summary

Official Symbol
MAP4K3provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3provided by HGNC
Primary source
HGNC:HGNC:6865
See related
Ensembl:ENSG00000011566 MIM:604921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1
Summary
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in thyroid (RPKM 14.7), testis (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See MAP4K3 in Genome Data Viewer
Location:
2p22.1
Exon count:
35
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (39248941..39437312, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39476407..39664453, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 10874 Neighboring gene cyclin dependent kinase like 4 Neighboring gene RNA, U6 small nuclear 373, pseudogene Neighboring gene MAP4K3 divergent transcript Neighboring gene transmembrane protein 178A Neighboring gene THUMP domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TNF receptor signaling pathway, organism-specific biosystem
    TNF receptor signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to UV IDA
Inferred from Direct Assay
more info
PubMed 
response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 3
Names
MAPK/ERK kinase kinase kinase 3
MEK kinase kinase 3
germinal center kinase-like kinase
germinal center kinase-related protein kinase
NP_001257354.1
NP_003609.2
XP_024308951.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028007.1 RefSeqGene

    Range
    4794..192813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270425.2NP_001257354.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001257354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC007684, AC079615, AK021553, AK314487, DA409370
    Consensus CDS
    CCDS58707.1
    UniProtKB/Swiss-Prot
    Q8IVH8
    UniProtKB/TrEMBL
    B3KMM5
    Related
    ENSP00000345434.5, ENST00000341681.9
    Conserved Domains (3) summary
    smart00036
    Location:540853
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. NM_003618.4NP_003609.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_003609.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007684, AC079615, AK021553, AK291467, DA409370
    Consensus CDS
    CCDS1803.1
    UniProtKB/Swiss-Prot
    Q8IVH8
    UniProtKB/TrEMBL
    A8K602, B3KMM5
    Related
    ENSP00000263881.3, ENST00000263881.8
    Conserved Domains (3) summary
    smart00036
    Location:561874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:15273
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    39248941..39437312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453183.1XP_024308951.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

    Conserved Domains (1) summary
    smart00036
    Location:114427
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

RNA

  1. XR_939730.2 RNA Sequence

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