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FGF4 fibroblast growth factor 4 [ Homo sapiens (human) ]

Gene ID: 2249, updated on 5-Sep-2020

Summary

Official Symbol
FGF4provided by HGNC
Official Full Name
fibroblast growth factor 4provided by HGNC
Primary source
HGNC:HGNC:3682
See related
Ensembl:ENSG00000075388 MIM:164980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See FGF4 in Genome Data Viewer
Location:
11q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (69771022..69775341, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69587797..69590171, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FGF19 upstream enhancer Neighboring gene DNAJB6 pseudogene 5 Neighboring gene FGF4 3' enhancer Neighboring gene FGF4 promoter region Neighboring gene FGF3 5' regulatory region Neighboring gene uncharacterized LOC107984368 Neighboring gene fibroblast growth factor 3 Neighboring gene anoctamin 1 Neighboring gene uncharacterized LOC105369371 Neighboring gene long intergenic non-protein coding RNA 2753

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies five new breast cancer susceptibility loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cartilage condensation IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
chondroblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cranial suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
mesenchymal cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 4
Names
heparin secretory transforming protein 1
heparin-binding growth factor 4
human stomach cancer, transforming factor from FGF-related oncogene
kaposi sarcoma oncogene
oncogene HST
transforming protein KS3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002007.4NP_001998.1  fibroblast growth factor 4 precursor

    See identical proteins and their annotated locations for NP_001998.1

    Status: REVIEWED

    Source sequence(s)
    AA974433, AP001888, AW340506, BF510715, CN429959, M17446
    Consensus CDS
    CCDS8194.1
    UniProtKB/Swiss-Prot
    P08620
    Related
    ENSP00000168712.1, ENST00000168712.3
    Conserved Domains (1) summary
    smart00442
    Location:80205
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    69771022..69775341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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