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Fgf4 fibroblast growth factor 4 [ Mus musculus (house mouse) ]

Gene ID: 14175, updated on 26-Sep-2022

Summary

Official Symbol
Fgf4provided by MGI
Official Full Name
fibroblast growth factor 4provided by MGI
Primary source
MGI:MGI:95518
See related
Ensembl:ENSMUSG00000050917 AllianceGenome:MGI:95518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KS3; hst; Fgfk; Hst1; kFGF; Fgf-4; Fgf7a; hst-1; HBGF-4; Hstf-1
Summary
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including animal organ morphogenesis; cellular response to leukemia inhibitory factor; and positive regulation of macromolecule metabolic process. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including branchial pouch; cerebellum; embryo mesenchyme; surface ectoderm; and tooth. Orthologous to human FGF4 (fibroblast growth factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Fgf4 in Genome Data Viewer
Location:
7 F5; 7 88.88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144415123..144418982)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144861386..144865245)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Fgf3 upstream enhancer Neighboring gene Fgf3 proximal promoter region Neighboring gene fibroblast growth factor 3 Neighboring gene Fgf4 promoter region Neighboring gene Fgf4 3' enhancer Neighboring gene Fgf15 upstream enhancer Neighboring gene Fgf15 5' regulatory region Neighboring gene predicted gene, 26793 Neighboring gene fibroblast growth factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129266, MGC129267

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chondroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cranial suture morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 4
Names
K-fibroblast growth factor
fibroblast growth factor 7a
heparin-binding growth factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010202.6NP_034332.2  fibroblast growth factor 4 precursor

    See identical proteins and their annotated locations for NP_034332.2

    Status: VALIDATED

    Source sequence(s)
    AC161763, AK082814, BB398533
    Consensus CDS
    CCDS22052.1
    UniProtKB/Swiss-Prot
    P11403, Q542N0
    UniProtKB/TrEMBL
    A0A7U3JW80, A0A8C6IGH4
    Related
    ENSMUSP00000056752.5, ENSMUST00000060336.5
    Conserved Domains (1) summary
    pfam00167
    Location:83199
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144415123..144418982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)