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Marchf2 membrane associated ring-CH-type finger 2 [ Mus musculus (house mouse) ]

Gene ID: 224703, updated on 2-Nov-2024

Summary

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Official Symbol
Marchf2provided by MGI
Official Full Name
membrane associated ring-CH-type finger 2provided by MGI
Primary source
MGI:MGI:1925915
See related
Ensembl:ENSMUSG00000079557 AllianceGenome:MGI:1925915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March2; MARCH-II; 9530046H09Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in antibacterial innate immune response and antiviral innate immune response. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum. Is expressed in several structures, including axial skeleton; bone; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14.5 (RPKM 31.0), liver E14 (RPKM 27.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Marchf2 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33904666..33937651, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33685692..33718677, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9. Sandow JJ, et al. Proteomics, 2021 Jun. PMID 33945654
  2. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Zeng LW, et al. Cell Mol Immunol, 2022 Oct. PMID 35982175, Free PMC Article
  3. Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. Chathuranga K, et al. EMBO J, 2020 Nov 2. PMID 32935379, Free PMC Article
  4. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. Han SO, et al. J Cell Biol, 2012 Nov 26. PMID 23166351, Free PMC Article
  5. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
    Title: The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
  2. Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
    Title: Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
  3. Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
    Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC7259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lysosomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF2
Names
E3 ubiquitin-protein ligase MARCH2
RING finger protein 172
RING-type E3 ubiquitin transferase MARCH2
RING-type E3 ubiquitin transferase MARCHF2
membrane-associated RING finger protein 2
membrane-associated RING-CH protein II
membrane-associated ring finger (C3HC4) 2
NP_001239409.1
NP_663461.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252480.1 → NP_001239409.1  E3 ubiquitin-protein ligase MARCHF2 isoform 2

    See identical proteins and their annotated locations for NP_001239409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK079234, AV336582, CT030732
    Consensus CDS
    CCDS57064.1
    UniProtKB/Swiss-Prot
    Q8C4Q5, Q99M02
    UniProtKB/TrEMBL
    Q8BPS3
    Related
    ENSMUSP00000134220.2, ENSMUST00000172767.9
    Conserved Domains (2) summary
    pfam00558
    Location:173 → 224
    Vpu; Vpu protein
    cd16808
    Location:62 → 113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

  2. NM_145486.5 → NP_663461.2  E3 ubiquitin-protein ligase MARCHF2 isoform 1

    See identical proteins and their annotated locations for NP_663461.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK039778, AK040163, BF729651, CA324654, CT030732
    Consensus CDS
    CCDS28627.1
    UniProtKB/TrEMBL
    Q8BPS3, Q8CA25
    Related
    ENSMUSP00000065225.7, ENSMUST00000066121.13
    Conserved Domains (2) summary
    pfam00558
    Location:173 → 224
    Vpu; Vpu protein
    smart00744
    Location:63 → 110
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RNA

  1. NR_045522.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040163, AK053434, BB634112, CT030732

  2. NR_045523.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040163, CT030732
    Related
    ENSMUST00000172934.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33904666..33937651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M02.1 GenPept UniProtKB/Swiss-Prot:Q99M02

Gene LinkOut

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