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Marchf2 membrane associated ring-CH-type finger 2 [ Mus musculus (house mouse) ]

Gene ID: 224703, updated on 8-Feb-2024

Summary

Official Symbol
Marchf2provided by MGI
Official Full Name
membrane associated ring-CH-type finger 2provided by MGI
Primary source
MGI:MGI:1925915
See related
Ensembl:ENSMUSG00000079557 AllianceGenome:MGI:1925915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March2; MARCH-II; 9530046H09Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within endocytosis. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum. Is expressed in several structures, including axial skeleton; bone; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 31.0), liver E14 (RPKM 27.2) and 28 other tissues See more
Orthologs
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Genomic context

See Marchf2 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33904666..33937651, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33685692..33718677, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC7259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lysosomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF2
Names
E3 ubiquitin-protein ligase MARCH2
RING finger protein 172
RING-type E3 ubiquitin transferase MARCH2
RING-type E3 ubiquitin transferase MARCHF2
membrane-associated RING finger protein 2
membrane-associated RING-CH protein II
membrane-associated ring finger (C3HC4) 2
NP_001239409.1
NP_663461.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252480.1NP_001239409.1  E3 ubiquitin-protein ligase MARCHF2 isoform 2

    See identical proteins and their annotated locations for NP_001239409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK079234, AV336582, CT030732
    Consensus CDS
    CCDS57064.1
    UniProtKB/Swiss-Prot
    Q8C4Q5, Q99M02
    UniProtKB/TrEMBL
    Q8BPS3
    Related
    ENSMUSP00000134220.2, ENSMUST00000172767.9
    Conserved Domains (2) summary
    pfam00558
    Location:173224
    Vpu; Vpu protein
    cd16808
    Location:62113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)
  2. NM_145486.5NP_663461.2  E3 ubiquitin-protein ligase MARCHF2 isoform 1

    See identical proteins and their annotated locations for NP_663461.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK039778, AK040163, BF729651, CA324654, CT030732
    Consensus CDS
    CCDS28627.1
    UniProtKB/TrEMBL
    Q8BPS3, Q8CA25
    Related
    ENSMUSP00000065225.7, ENSMUST00000066121.13
    Conserved Domains (2) summary
    pfam00558
    Location:173224
    Vpu; Vpu protein
    smart00744
    Location:63110
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RNA

  1. NR_045522.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040163, AK053434, BB634112, CT030732
  2. NR_045523.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK040163, CT030732
    Related
    ENSMUST00000172934.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33904666..33937651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)