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MARCH2 membrane associated ring-CH-type finger 2 [ Homo sapiens (human) ]

Gene ID: 51257, updated on 19-Jun-2019

Summary

Official Symbol
MARCH2provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 2provided by HGNC
Primary source
HGNC:HGNC:28038
See related
Ensembl:ENSG00000099785 MIM:613332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF172; HSPC240; MARCH-II
Summary
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in fat (RPKM 20.9), heart (RPKM 12.9) and 25 other tissues See more
Orthologs

Genomic context

See MARCH2 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8413303..8439017)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8478187..8503901)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB11B antisense RNA 1 Neighboring gene microRNA 4999 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene PML-RARA regulated adaptor molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCH2
Names
RING finger protein 172
RING-type E3 ubiquitin transferase MARCH2
membrane associated ring finger 2
membrane-associated RING finger protein 2
membrane-associated RING-CH protein II
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
NP_001005415.1
NP_001005416.1
NP_001356705.1
NP_001356706.1
NP_001356707.1
NP_001356708.1
NP_057580.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005415.1NP_001005415.1  E3 ubiquitin-protein ligase MARCH2 isoform 1

    See identical proteins and their annotated locations for NP_001005415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AF151074, BC015910, BC032624, BI546028, CN363445
    Consensus CDS
    CCDS12202.1
    UniProtKB/Swiss-Prot
    Q9P0N8
    Related
    ENSP00000215555.2, ENST00000215555.6
    Conserved Domains (2) summary
    pfam00558
    Location:172223
    Vpu; Vpu protein
    cd16808
    Location:62113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)
  2. NM_001005416.2NP_001005416.1  E3 ubiquitin-protein ligase MARCH2 isoform 2

    See identical proteins and their annotated locations for NP_001005416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AF151074, BC015910, BC032624, BI546028, CN363445
    Consensus CDS
    CCDS32894.1
    UniProtKB/Swiss-Prot
    Q9P0N8
    Related
    ENSP00000370423.3, ENST00000381035.8
    Conserved Domains (1) summary
    cd16808
    Location:62113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)
  3. NM_001369776.1NP_001356705.1  E3 ubiquitin-protein ligase MARCH2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AC136469
  4. NM_001369777.1NP_001356706.1  E3 ubiquitin-protein ligase MARCH2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AC136469
  5. NM_001369778.1NP_001356707.1  E3 ubiquitin-protein ligase MARCH2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AC136469
  6. NM_001369779.1NP_001356708.1  E3 ubiquitin-protein ligase MARCH2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AC136469, BC032624
  7. NM_016496.5NP_057580.3  E3 ubiquitin-protein ligase MARCH2 isoform 1

    See identical proteins and their annotated locations for NP_057580.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform (1).
    Source sequence(s)
    AF151074, BC015910, BC032624, BI546028, CN363445
    Consensus CDS
    CCDS12202.1
    UniProtKB/Swiss-Prot
    Q9P0N8
    Related
    ENSP00000471536.1, ENST00000602117.1
    Conserved Domains (2) summary
    pfam00558
    Location:172223
    Vpu; Vpu protein
    cd16808
    Location:62113
    RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

RNA

  1. NR_163145.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136469

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8413303..8439017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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