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FGF2 fibroblast growth factor 2 [ Homo sapiens (human) ]

Gene ID: 2247, updated on 10-May-2020

Summary

Official Symbol
FGF2provided by HGNC
Official Full Name
fibroblast growth factor 2provided by HGNC
Primary source
HGNC:HGNC:3676
See related
Ensembl:ENSG00000138685 MIM:134920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BFGF; FGFB; FGF-2; HBGF-2
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues See more
Orthologs

Genomic context

See FGF2 in Genome Data Viewer
Location:
4q28.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (122826708..122898236)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (123747568..123819390)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2230 Neighboring gene FGF2 promoter region Neighboring gene ribosomal protein L34 pseudogene 12 Neighboring gene ribosomal protein S26 pseudogene 23 Neighboring gene Sharpr-MPRA regulatory region 4593 Neighboring gene nudix hydrolase 6 Neighboring gene spermatogenesis associated 5 Neighboring gene coilin pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120-induced apoptosis in cell cultures through binding to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and pro-apoptotic molecule Bax PubMed
Nef nef HIV-1 Nef synergizes with IL-6 to upregulate expression of basic fibroblast growth factor and cyclin D1 in NIH3T3-induced tissues PubMed
Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A and FGF-2 PubMed
tat HIV-1 Tat protein, but not HIV-1 Nef and gp120 proteins, competes with FGF-2 for binding to fibroblast growth factor binding protein 1 (FGF-BP1) PubMed
tat The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes PubMed
tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
tat HIV-1 Tat induces endothelial cells to progress through the G1 phase in response to bFGF, and this process is linked to ERK activation PubMed
tat HIV-1 Tat competes with bFGF for binding to Heparin, an effect mediated by the basic region of Tat (amino acids 49-57) PubMed
tat HIV-1 Tat inhibits bFGF-induced secretion of tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and TIMP-2) PubMed
tat HIV-1 Tat synergizes with bFGF to promote Kaposi's sarcoma, endothelial cell growth and locomotion, and secretion of matrix-metalloproteinase-2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor-receptor interaction IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
chondroblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
embryonic morphogenesis TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
growth factor dependent regulation of skeletal muscle satellite cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
paracrine signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endothelial cell chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell migration involved in sprouting angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor NAS
Non-traceable Author Statement
more info
PubMed 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
somatic stem cell population maintenance TAS
Traceable Author Statement
more info
 
stem cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
wound healing IDA
Inferred from Direct Assay
more info
PubMed 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor 2
Names
basic fibroblast growth factor bFGF
fibroblast growth factor 2 (basic)
heparin-binding growth factor 2
prostatropin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029067.2 RefSeqGene

    Range
    5124..76529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361665.2NP_001348594.1  fibroblast growth factor 2 isoform 18 kDa

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) may encode multiple distinct isoforms through the use of alternative translation start codons (PMID: 17131363). This record represents use of the most conserved AUG start codon and encodes the shortest (18-kDa) isoform.
    Source sequence(s)
    AA256481, AC021205, AI276765, BP292299, BU501243, CN315083, J04513, M27968
    Related
    ENSP00000494222.1, ENST00000644866.2
    Conserved Domains (1) summary
    pfam00167
    Location:28149
    FGF; Fibroblast growth factor
  2. NM_002006.5NP_001997.5  fibroblast growth factor 2 isoform 34 kDa

    See identical proteins and their annotated locations for NP_001997.5

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) may encode multiple distinct isoforms through the use of alternative translation start codons (PMID: 17131363). This record represents use of the 5' most non-AUG start codon and encodes the longest (34-kDa) isoform.
    Source sequence(s)
    AA256481, AC021205, AI276765, CN315083, J04513
    Consensus CDS
    CCDS34059.1
    UniProtKB/Swiss-Prot
    P09038
    UniProtKB/TrEMBL
    A0A087WUF6
    Related
    ENSP00000264498.3, ENST00000264498.7
    Conserved Domains (1) summary
    pfam00167
    Location:161282
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    122826708..122898236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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