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FGF1 fibroblast growth factor 1 [ Homo sapiens (human) ]

Gene ID: 2246, updated on 2-Aug-2020

Summary

Official Symbol
FGF1provided by HGNC
Official Full Name
fibroblast growth factor 1provided by HGNC
Primary source
HGNC:HGNC:3665
See related
Ensembl:ENSG00000113578 MIM:131220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Expression
Biased expression in brain (RPKM 36.0), kidney (RPKM 21.0) and 4 other tissues See more
Orthologs

Genomic context

See FGF1 in Genome Data Viewer
Location:
5q31.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (142592178..142698070, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141971743..142077635, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1640 Neighboring gene ribosomal protein S12 pseudogene 10 Neighboring gene FGF1 promoter D Neighboring gene FGF1 promoter C Neighboring gene FGF1 promoter B Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neurotoxic effects are inhibited by the presence of fibroblast growth factor 1 (FGF1) PubMed
Tat tat HIV-1 Tat induces the expression and secretion of FGF-1 from primary murine embryonic fibroblasts, an effect that may be relevant to the pathophysiological development of AIDS associated Kaposi's sarcoma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branch elongation involved in ureteric bud branching IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
lung development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lung development IEA
Inferred from Electronic Annotation
more info
 
mesonephric epithelium development IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
organ induction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 1
Names
beta-endothelial cell growth factor
endothelial cell growth factor, alpha
endothelial cell growth factor, beta
fibroblast growth factor 1 (acidic)
heparin-binding growth factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000800.5NP_000791.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000791.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the full-length isoform (1). Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA189432
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000338548.2, ENST00000337706.7
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  2. NM_001144892.3NP_001138364.1  fibroblast growth factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001138364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, BC032697
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000352329.6, ENST00000359370.10
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  3. NM_001144934.2NP_001138406.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA649213
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000404742.2, ENST00000441680.6
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  4. NM_001144935.2NP_001138407.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA389088, DC344309
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000396195.2, ENST00000419524.6
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  5. NM_001257205.1NP_001244134.1  fibroblast growth factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001244134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DC344309, DQ655917
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000480791.1, ENST00000621536.4
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  6. NM_001257206.2NP_001244135.1  fibroblast growth factor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001244135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, AK289762, DC344309
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25147
    FGF; Fibroblast growth factor
  7. NM_001257207.1NP_001244136.1  fibroblast growth factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001244136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, AK312301
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000479024.1, ENST00000612258.4
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  8. NM_001257208.2NP_001244137.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DB220987
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000367285.1, ENST00000378046.5
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  9. NM_001257209.1NP_001244138.1  fibroblast growth factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001244138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA111414, DB220987
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000480980.1, ENST00000619447.4
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  10. NM_001257210.1NP_001244139.1  fibroblast growth factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001244139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA660034
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000481868.1, ENST00000610990.4
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  11. NM_001257211.2NP_001244140.1  fibroblast growth factor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001244140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, DA388578, DB220987
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25147
    FGF; Fibroblast growth factor
  12. NM_001257212.2NP_001244141.1  fibroblast growth factor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001244141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, DA575048
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25147
    FGF; Fibroblast growth factor
  13. NM_001354951.2NP_001341880.1  fibroblast growth factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1, 4-7, 9-12, and 16-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  14. NM_001354952.2NP_001341881.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1, 4-7, 9-12, 15, and 17-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  15. NM_001354953.2NP_001341882.1  fibroblast growth factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1, 4-7, 9-12, 15, 16 and 18-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  16. NM_001354954.2NP_001341883.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 4-7, 9-12, 15-17, 19, and 20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  17. NM_001354955.2NP_001341884.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 4-7, 9-12, 15-18, and 20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  18. NM_001354956.2NP_001341885.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 1, 4-7, 9-12, and 15-19, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    Conserved Domains (1) summary
    pfam00167
    Location:25148
    FGF; Fibroblast growth factor
  19. NM_001354957.2NP_001341886.1  fibroblast growth factor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 8, 13, 14, and 22, encodes isoform 4.
    Source sequence(s)
    AC005370, AC005592
    Conserved Domains (1) summary
    pfam00167
    Location:25147
    FGF; Fibroblast growth factor
  20. NM_001354958.2NP_001341887.1  fibroblast growth factor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 8, 13, 14, and 21, encodes isoform 4.
    Source sequence(s)
    AC005370, AC005592
    Conserved Domains (1) summary
    pfam00167
    Location:25147
    FGF; Fibroblast growth factor
  21. NM_001354959.2NP_001341888.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 2 and 24-27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  22. NM_001354961.2NP_001341890.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 2, 23, and 25-27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  23. NM_001354962.2NP_001341891.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 2, 23, 24, 26, and 27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  24. NM_001354963.2NP_001341892.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 2, 23-25, and 27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  25. NM_001354964.2NP_001341893.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 2 and 23-26, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  26. NM_033136.4NP_149127.1  fibroblast growth factor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_149127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 23-27 encode the same isoform (2).
    Source sequence(s)
    AC005370, AI283639, DA326831
    Consensus CDS
    CCDS4276.1
    UniProtKB/Swiss-Prot
    P05230
    Related
    ENSP00000354231.5, ENST00000360966.9
    Conserved Domains (1) summary
    cl00060
    Location:2557
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  27. NM_033137.4NP_149128.1  fibroblast growth factor 1 isoform 3

    See identical proteins and their annotated locations for NP_149128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks a coding exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005370, AC005592
    UniProtKB/TrEMBL
    Q16089
    Conserved Domains (1) summary
    cl00060
    Location:2556
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    142592178..142698070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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