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FGB fibrinogen beta chain [ Homo sapiens (human) ]

Gene ID: 2244, updated on 4-Oct-2020

Summary

Official Symbol
FGBprovided by HGNC
Official Full Name
fibrinogen beta chainprovided by HGNC
Primary source
HGNC:HGNC:3662
See related
Ensembl:ENSG00000171564 MIM:134830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-78p
Summary
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Restricted expression toward liver (RPKM 2456.5) See more
Orthologs

Genomic context

See FGB in Genome Data Viewer
Location:
4q31.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (154562980..154572807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (155484132..155493915)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene pleiotropic regulator 1 Neighboring gene RNA, U6 small nuclear 1285, pseudogene Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene fibrinogen alpha chain Neighboring gene fibrinogen gamma chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Afibrinogenemia, congenital
MedGen: C2584774 OMIM: 202400 GeneReviews: Not available
Compare labs
Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.
GeneReviews: Not available
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
GeneReviews: Not available
Dysfibrinogenemia, congenital
MedGen: C0272350 OMIM: 616004 GeneReviews: Not available
Compare labs
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
GeneReviews: Not available
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104327, MGC120405

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
extracellular matrix structural constituent HDA PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation, fibrin clot formation IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to leptin stimulus IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
fibrinolysis IDA
Inferred from Direct Assay
more info
PubMed 
induction of bacterial agglutination IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptide hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicle HDA PubMed 
fibrinogen complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibrinogen beta chain
Names
beta-fibrinogen
epididymis secretory sperm binding protein Li 78p
fibrinogen, B beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008833.1 RefSeqGene

    Range
    5001..14784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_558

mRNA and Protein(s)

  1. NM_001184741.1NP_001171670.1  fibrinogen beta chain isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001171670.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC107385, AK312972, BC036007
    UniProtKB/Swiss-Prot
    P02675
    Conserved Domains (2) summary
    pfam08702
    Location:57175
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:178427
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_001382759.1NP_001369688.1  fibrinogen beta chain isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  3. NM_001382760.1NP_001369689.1  fibrinogen beta chain isoform 4 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  4. NM_001382761.1NP_001369690.1  fibrinogen beta chain isoform 5 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  5. NM_001382762.1NP_001369691.1  fibrinogen beta chain isoform 6 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  6. NM_001382763.1NP_001369692.1  fibrinogen beta chain isoform 7 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  7. NM_001382764.1NP_001369693.1  fibrinogen beta chain isoform 8 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  8. NM_001382765.1NP_001369694.1  fibrinogen beta chain isoform 9 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC107385
  9. NM_005141.5NP_005132.2  fibrinogen beta chain isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005132.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC107385, AK312972, J00129
    Consensus CDS
    CCDS3786.1
    UniProtKB/Swiss-Prot
    P02675
    UniProtKB/TrEMBL
    V9HVY1
    Related
    ENSP00000306099.4, ENST00000302068.8
    Conserved Domains (2) summary
    cl00085
    Location:237486
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:92234
    Fib_alpha; Fibrinogen alpha/beta chain family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    154562980..154572807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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