U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fgb fibrinogen beta chain [ Mus musculus (house mouse) ]

Gene ID: 110135, updated on 27-Nov-2024

Summary

Official Symbol
Fgbprovided by MGI
Official Full Name
fibrinogen beta chainprovided by MGI
Primary source
MGI:MGI:99501
See related
Ensembl:ENSMUSG00000033831 AllianceGenome:MGI:99501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510049G14Rik
Summary
This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]
Expression
Biased expression in liver E18 (RPKM 4980.3), liver adult (RPKM 857.2) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fgb in Genome Data Viewer
Location:
3 E3; 3 36.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82949553..82957170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83042246..83049863, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08043 Neighboring gene STARR-seq mESC enhancer starr_08044 Neighboring gene STARR-seq mESC enhancer starr_08045 Neighboring gene STARR-positive B cell enhancer mm9_chr3:82859171-82859472 Neighboring gene predicted gene, 40075 Neighboring gene fibrinogen alpha chain Neighboring gene pleiotropic regulator 1 Neighboring gene predicted gene 10710 Neighboring gene dachsous cadherin related 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in blood coagulation, fibrin clot formation IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leptin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in induction of bacterial agglutination IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of bacterial agglutination ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 
located_in blood microparticle ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of fibrinogen complex IEA
Inferred from Electronic Annotation
more info
 
part_of fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule IEA
Inferred from Electronic Annotation
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibrinogen beta chain
Names
fibrinogen, B beta polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181849.3NP_862897.1  fibrinogen beta chain preproprotein

    See identical proteins and their annotated locations for NP_862897.1

    Status: REVIEWED

    Source sequence(s)
    AC138394, AK168626, AW110458
    Consensus CDS
    CCDS17432.1
    UniProtKB/Swiss-Prot
    Q8K0E8, Q91ZP1
    UniProtKB/TrEMBL
    Q3TGR2
    Related
    ENSMUSP00000039472.4, ENSMUST00000048246.5
    Conserved Domains (2) summary
    pfam08702
    Location:82224
    Fib_alpha; Fibrinogen alpha/beta chain family
    cl00085
    Location:227476
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    82949553..82957170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)