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Wnt7a wingless-type MMTV integration site family, member 7A [ Mus musculus (house mouse) ]

Gene ID: 22421, updated on 11-Apr-2024

Summary

Official Symbol
Wnt7aprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 7Aprovided by MGI
Primary source
MGI:MGI:98961
See related
Ensembl:ENSMUSG00000030093 AllianceGenome:MGI:98961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
px; tw; Wnt-7a
Summary
Enables frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic limb morphogenesis. Located in cell surface; extracellular matrix; and glutamatergic synapse. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 11.5), CNS E18 (RPKM 6.0) and 10 other tissues See more
Orthologs
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Genomic context

See Wnt7a in Genome Data Viewer
Location:
6 D1; 6 40.45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91340963..91388335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91363981..91411353, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53298 Neighboring gene fibulin 2 Neighboring gene predicted gene, 30437 Neighboring gene vomeronasal 1 receptor, pseudogene 35 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (3) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within asymmetric protein localization involved in cell fate determination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell proliferation in forebrain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within central nervous system vasculogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebellar granule cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic axis specification ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
involved_in embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of blood-brain barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
involved_in limb development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in oviduct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation involved in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory synapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axon diameter IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive structure development IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within response to estrogen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secondary palate development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within skin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within somatic stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uterus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-7a
Names
postaxial hemimelia
wingless-related MMTV integration site 7A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363757.1NP_001350686.1  protein Wnt-7a isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC121990, AC161456
    Conserved Domains (1) summary
    cl19568
    Location:40145
    wnt; wnt family
  2. NM_009527.4NP_033553.2  protein Wnt-7a isoform 1 precursor

    See identical proteins and their annotated locations for NP_033553.2

    Status: VALIDATED

    Source sequence(s)
    AK004683, BC057586
    Consensus CDS
    CCDS39568.1
    UniProtKB/Swiss-Prot
    P24383, Q80VH3, Q9DBY3
    Related
    ENSMUSP00000032180.7, ENSMUST00000032180.7
    Conserved Domains (1) summary
    cd19349
    Location:32349
    Wnt_Wnt7a; Wnt domain found in protein Wnt-7a and similar proteins

RNA

  1. NR_177083.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121990, AC161456

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    91340963..91388335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166027.1XP_036021920.1  protein Wnt-7a isoform X1

    Conserved Domains (1) summary
    cl38924
    Location:1282
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family