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WNT7A Wnt family member 7A [ Homo sapiens (human) ]

Gene ID: 7476, updated on 6-Sep-2021

Summary

Official Symbol
WNT7Aprovided by HGNC
Official Full Name
Wnt family member 7Aprovided by HGNC
Primary source
HGNC:HGNC:12786
See related
Ensembl:ENSG00000154764 MIM:601570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Wnt-7a
Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.1), placenta (RPKM 2.3) and 9 other tissues See more
Orthologs
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Genomic context

See WNT7A in Genome Data Viewer
Location:
3p25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (13816258..13880071, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13857755..13921568, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 620 Neighboring gene Sharpr-MPRA regulatory region 4110 Neighboring gene tRNA suppressor (anticodon CTA) 2-1 Neighboring gene Sharpr-MPRA regulatory region 1149 Neighboring gene uncharacterized LOC105376957 Neighboring gene vomeronasal 1 receptor 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Fuhrmann syndrome
MedGen: C1856728 OMIM: 228930 GeneReviews: Not available
Compare labs
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available
Schinzel phocomelia syndrome
MedGen: C1848651 OMIM: 276820 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IC
Inferred by Curator
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in asymmetric protein localization involved in cell fate determination IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cartilage condensation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell proliferation in forebrain IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar granule cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory synapse assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in oviduct development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell proliferation involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to presynapse TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of axon diameter IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynapse assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sex differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle satellite cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
involved_in uterus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing, spreading of epidermal cells IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular exosome TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Wnt-7a
Names
proto-oncogene Wnt7a protein
wingless-type MMTV integration site family, member 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008088.1 RefSeqGene

    Range
    5001..66537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004625.4NP_004616.2  protein Wnt-7a precursor

    See identical proteins and their annotated locations for NP_004616.2

    Status: REVIEWED

    Source sequence(s)
    AC090646, BC008811
    Consensus CDS
    CCDS2616.1
    UniProtKB/Swiss-Prot
    O00755
    Related
    ENSP00000285018.4, ENST00000285018.5
    Conserved Domains (1) summary
    cd19349
    Location:32349
    Wnt_Wnt7a; Wnt domain found in protein Wnt-7a and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    13816258..13880071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534091.2XP_011532393.1  protein Wnt-7a isoform X1

    See identical proteins and their annotated locations for XP_011532393.1

    Conserved Domains (1) summary
    cl38924
    Location:1282
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
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