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WNT7A Wnt family member 7A [ Homo sapiens (human) ]

Gene ID: 7476, updated on 1-Jun-2020

Summary

Official Symbol
WNT7Aprovided by HGNC
Official Full Name
Wnt family member 7Aprovided by HGNC
Primary source
HGNC:HGNC:12786
See related
Ensembl:ENSG00000154764 MIM:601570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Wnt-7a
Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.1), placenta (RPKM 2.3) and 9 other tissues See more
Orthologs

Genomic context

See WNT7A in Genome Data Viewer
Location:
3p25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (13816258..13880071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13860082..13921618, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 620 Neighboring gene Sharpr-MPRA regulatory region 4110 Neighboring gene tRNA suppressor (anticodon CTA) 2-1 Neighboring gene uncharacterized LOC105376957 Neighboring gene vomeronasal 1 receptor 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Fuhrmann syndrome
MedGen: C1856728 OMIM: 228930 GeneReviews: Not available
Compare labs
Schinzel phocomelia syndrome
MedGen: C1848651 OMIM: 276820 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity IC
Inferred by Curator
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
asymmetric protein localization involved in cell fate determination IEA
Inferred from Electronic Annotation
more info
 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cartilage condensation IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation in forebrain IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
cerebellar granule cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse assembly TAS
Traceable Author Statement
more info
PubMed 
lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
oviduct development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to presynapse TAS
Traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse assembly TAS
Traceable Author Statement
more info
PubMed 
presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of axon diameter IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly EXP
Inferred from Experiment
more info
PubMed 
regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sex differentiation TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle satellite cell activation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell development IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
uterus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of epidermal cells IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Wnt-7a
Names
proto-oncogene Wnt7a protein
wingless-type MMTV integration site family, member 7A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008088.1 RefSeqGene

    Range
    5001..66537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004625.4NP_004616.2  protein Wnt-7a precursor

    See identical proteins and their annotated locations for NP_004616.2

    Status: REVIEWED

    Source sequence(s)
    AC090646, BC008811
    Consensus CDS
    CCDS2616.1
    UniProtKB/Swiss-Prot
    O00755
    Related
    ENSP00000285018.4, ENST00000285018.5
    Conserved Domains (1) summary
    smart00097
    Location:40349
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    13816258..13880071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534091.2XP_011532393.1  protein Wnt-7a isoform X1

    See identical proteins and their annotated locations for XP_011532393.1

    Conserved Domains (1) summary
    smart00097
    Location:1282
    WNT1; found in Wnt-1
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